Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 97392..97939 Replicon chromosome
Accession NZ_CP017802
Organism Raoultella ornithinolytica strain MG isolate MG01

Toxin (Protein)


Gene name ccdB Uniprot ID A0A808XUV0
Locus tag BK817_RS00485 Protein ID WP_048025274.1
Coordinates 97631..97939 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A808XYT1
Locus tag BK817_RS00480 Protein ID WP_004869059.1
Coordinates 97392..97628 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK817_RS00465 93598..94761 + 1164 WP_004869055.1 multidrug effflux MFS transporter -
BK817_RS00470 94926..95828 + 903 WP_044350979.1 N-acetylmuramic acid 6-phosphate etherase -
BK817_RS00475 95853..97286 + 1434 WP_004869058.1 PTS N-acetylmuramic acid transporter subunit IIBC -
BK817_RS00480 97392..97628 + 237 WP_004869059.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BK817_RS00485 97631..97939 + 309 WP_048025274.1 CcdB family protein Toxin
BK817_RS00490 98055..98957 + 903 WP_015585496.1 EamA family transporter -
BK817_RS00495 99066..99341 + 276 WP_162098187.1 hypothetical protein -
BK817_RS00500 99436..100377 - 942 WP_015585487.1 LacI family transcriptional regulator -
BK817_RS00505 100672..100986 + 315 WP_004869063.1 PTS sugar transporter subunit IIB -
BK817_RS00510 100998..102323 + 1326 WP_004869064.1 PTS cellobiose transporter subunit IIC -
BK817_RS00515 102458..102760 + 303 WP_015585486.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11778.62 Da        Isoelectric Point: 6.7156

>T68163 WP_048025274.1 NZ_CP017802:97631-97939 [Raoultella ornithinolytica]
IQYYVYKNTGRITVYPYLLDVQSDIIGMRNTRVVIPLFPLRNYKGPRADRLTPVVTVEGEEYVVMTHELASIPQRVLGEE
VCHLNHQREVVKASIDFLFDGI

Download         Length: 309 bp

>T68163 NZ_CP017802:97631-97939 [Raoultella ornithinolytica]
ATACAGTATTACGTTTATAAAAATACCGGTCGAATTACTGTGTATCCTTATCTCCTTGATGTACAAAGTGACATTATTGG
AATGCGCAATACCCGGGTCGTGATCCCACTATTCCCGCTGAGAAATTACAAAGGTCCGCGCGCCGATCGTTTAACACCGG
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACAACGCGTTCTGGGGGAAGAG
GTTTGTCATCTCAATCACCAACGTGAAGTCGTTAAAGCATCAATAGATTTTCTTTTTGACGGGATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8898.08 Da        Isoelectric Point: 5.6579

>AT68163 WP_004869059.1 NZ_CP017802:97392-97628 [Raoultella ornithinolytica]
MPAVKHNKQNVSVTLDPILVKQAREIGINLSQTLTSALKSEIHSIEMARWQKENARAIDYLNDLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT68163 NZ_CP017802:97392-97628 [Raoultella ornithinolytica]
ATGCCAGCCGTAAAACACAATAAGCAGAATGTCAGCGTGACGCTGGATCCTATACTGGTCAAACAGGCTCGTGAGATCGG
CATCAATCTTTCTCAAACGTTGACGAGCGCTCTAAAAAGCGAAATCCACAGCATCGAAATGGCACGCTGGCAAAAAGAAA
ATGCCAGGGCAATCGACTACCTCAATGATTTAACAGAGGAAAATGGACTTCTCTCTGACGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XUV0

Antitoxin

Source ID Structure
AlphaFold DB A0A808XYT1

References