Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1726309..1726944 Replicon chromosome
Accession NZ_CP017770
Organism Paenibacillus crassostreae strain LPB0068

Toxin (Protein)


Gene name mazF Uniprot ID A0A167GLA7
Locus tag LPB68_RS08255 Protein ID WP_068654481.1
Coordinates 1726309..1726659 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A167GMN2
Locus tag LPB68_RS08260 Protein ID WP_068654565.1
Coordinates 1726663..1726944 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB68_RS08245 1721468..1723639 - 2172 WP_068654563.1 RNA-binding transcriptional accessory protein -
LPB68_RS08250 1723881..1726070 - 2190 WP_068654479.1 alpha-galactosidase -
LPB68_RS08255 1726309..1726659 - 351 WP_068654481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPB68_RS08260 1726663..1726944 - 282 WP_068654565.1 ribbon-helix-helix protein, CopG family Antitoxin
LPB68_RS08265 1727226..1728410 - 1185 WP_099458638.1 alanine racemase -
LPB68_RS08270 1728615..1729706 - 1092 WP_068654485.1 outer membrane lipoprotein carrier protein LolA -
LPB68_RS08275 1729922..1731520 + 1599 WP_068654487.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12835.85 Da        Isoelectric Point: 5.1393

>T68128 WP_068654481.1 NZ_CP017770:c1726659-1726309 [Paenibacillus crassostreae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAISHGFDRDSVILLEQV
RTIDKQRLTDKITHLDEETMKKVDEALLISLSLIDF

Download         Length: 351 bp

>T68128 NZ_CP017770:c1726659-1726309 [Paenibacillus crassostreae]
TTGATTGTAAAACGCGGTGATGTGTTTTTTGCGGACCTCTCACCTGTTGTTGGTTCTGAACAGGGAGGGGTGAGGCCTGT
TTTAATCATACAGAATGATATCGGTAATCGCTTTAGCCCAACGGCGATCGTAGCGGCGATTACTGCGCAGATTCAAAAGG
CGAAGCTCCCAACACATGTAGAGATTGATGCAATCTCTCATGGATTTGATCGAGATTCCGTTATTCTGCTGGAACAGGTT
CGAACGATTGACAAACAAAGATTAACGGATAAGATCACTCATCTCGATGAAGAAACAATGAAAAAAGTAGATGAGGCTTT
GTTGATCAGTCTCAGCTTAATTGATTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10645.30 Da        Isoelectric Point: 7.2027

>AT68128 WP_068654565.1 NZ_CP017770:c1726944-1726663 [Paenibacillus crassostreae]
VANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSELIRQAMKLYLMERKKRYIRESMQRGYMEMAKINLTMASEAFHAEE
DADSTLGRAVSGV

Download         Length: 282 bp

>AT68128 NZ_CP017770:c1726944-1726663 [Paenibacillus crassostreae]
GTGGCTAATTTGCAGAACACCAAAAGAATTATGATCAGTTTACCGGATCATCTTTTGCAGGAAGTGGACGGAATCGTCGC
AATGGAGAATTCCAATCGTAGTGAACTCATTAGACAGGCCATGAAATTGTATTTGATGGAGCGGAAGAAAAGATACATTC
GCGAGTCTATGCAGCGTGGCTACATGGAAATGGCCAAAATTAATTTGACCATGGCTTCTGAGGCATTTCACGCAGAGGAA
GATGCAGACAGCACTCTAGGCCGCGCAGTGAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167GLA7

Antitoxin

Source ID Structure
AlphaFold DB A0A167GMN2

References