Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3449149..3449732 Replicon chromosome
Accession NZ_CP017762
Organism Virgibacillus sp. 6R

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BKP57_RS15700 Protein ID WP_072741933.1
Coordinates 3449400..3449732 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BKP57_RS15695 Protein ID WP_050353472.1
Coordinates 3449149..3449400 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKP57_RS15680 3446142..3446819 - 678 WP_050351192.1 ABC transporter ATP-binding protein -
BKP57_RS15685 3446927..3447847 - 921 WP_156875354.1 HAMP domain-containing histidine kinase -
BKP57_RS15690 3447847..3448524 - 678 WP_198035056.1 response regulator transcription factor -
BKP57_RS15695 3449149..3449400 + 252 WP_050353472.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKP57_RS15700 3449400..3449732 + 333 WP_072741933.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BKP57_RS15705 3449864..3450187 + 324 WP_072741934.1 thermonuclease family protein -
BKP57_RS15710 3451043..3451336 - 294 WP_050351190.1 DUF1433 domain-containing protein -
BKP57_RS15715 3451449..3451763 + 315 WP_156875355.1 hypothetical protein -
BKP57_RS15720 3451870..3452085 + 216 WP_082240897.1 hypothetical protein -
BKP57_RS15725 3452045..3452284 + 240 WP_050351188.1 hypothetical protein -
BKP57_RS22240 3452299..3452475 + 177 WP_156875356.1 hypothetical protein -
BKP57_RS15730 3452866..3453411 + 546 WP_050351187.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(9-53)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12054.95 Da        Isoelectric Point: 6.9497

>T68124 WP_072741933.1 NZ_CP017762:3449400-3449732 [Virgibacillus sp. 6R]
MVAPERGDLVYVDFDAQSGREQAGIRPAIVLSPKQFNQITGFTVLCPITKTVRGWGYEVALPDGLAVSGVILTDKVKSVD
WNTRKLKIKGQAPEEIVEDCLAKIHTFLGQ

Download         Length: 333 bp

>T68124 NZ_CP017762:3449400-3449732 [Virgibacillus sp. 6R]
ATGGTAGCACCAGAACGCGGCGATCTTGTATATGTGGATTTCGATGCGCAATCAGGACGTGAACAGGCTGGTATAAGACC
TGCGATTGTCCTATCCCCTAAACAATTCAATCAAATCACAGGATTTACTGTTCTGTGCCCAATTACAAAAACCGTCAGGG
GCTGGGGTTATGAAGTTGCGCTTCCTGACGGTTTAGCTGTGTCAGGAGTTATACTCACTGACAAAGTAAAAAGCGTAGAT
TGGAATACCAGAAAGTTAAAAATAAAAGGACAAGCTCCAGAAGAAATCGTTGAAGATTGCCTAGCTAAAATACATACATT
TTTAGGGCAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.61 Da        Isoelectric Point: 5.6713

>AT68124 WP_050353472.1 NZ_CP017762:3449149-3449400 [Virgibacillus sp. 6R]
MTATATVSKWGNSLGVRIPKDMADSANINQGTEMTITLDQKGQIILTPIKNKKEYSLDELLNQCKPEHRHQEIDFGIKGE
ELI

Download         Length: 252 bp

>AT68124 NZ_CP017762:3449149-3449400 [Virgibacillus sp. 6R]
ATGACTGCAACCGCTACTGTATCAAAATGGGGTAATAGTTTAGGGGTTAGAATTCCAAAAGACATGGCTGATTCAGCAAA
TATTAATCAAGGAACAGAAATGACAATTACTCTGGATCAAAAAGGACAAATCATTTTGACACCGATTAAGAATAAAAAAG
AATATTCCTTAGATGAATTATTAAATCAATGCAAACCAGAGCATCGTCATCAAGAAATTGATTTCGGAATAAAGGGGGAG
GAATTAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References