Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2280466..2281041 Replicon chromosome
Accession NZ_CP017761
Organism Marinilactibacillus sp. 15R

Toxin (Protein)


Gene name mazF Uniprot ID A0A1L4C165
Locus tag BKP56_RS11245 Protein ID WP_072695163.1
Coordinates 2280466..2280810 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L4C111
Locus tag BKP56_RS11250 Protein ID WP_072695164.1
Coordinates 2280811..2281041 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKP56_RS11225 2275632..2277056 - 1425 WP_072695160.1 PTS sugar transporter subunit IIC -
BKP56_RS11230 2277268..2278581 - 1314 WP_156849251.1 6-phospho-beta-glucosidase -
BKP56_RS11235 2278733..2279452 + 720 WP_072695161.1 GntR family transcriptional regulator -
BKP56_RS11240 2279479..2280180 + 702 WP_072695162.1 chitin disaccharide deacetylase -
BKP56_RS11245 2280466..2280810 - 345 WP_072695163.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BKP56_RS11250 2280811..2281041 - 231 WP_072695164.1 AbrB family transcriptional regulator Antitoxin
BKP56_RS11255 2281703..2281927 - 225 WP_072695165.1 hypothetical protein -
BKP56_RS11260 2282049..2283347 - 1299 WP_156849252.1 TIGR02679 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13020.91 Da        Isoelectric Point: 8.8346

>T68122 WP_072695163.1 NZ_CP017761:c2280810-2280466 [Marinilactibacillus sp. 15R]
MSVDKYIPHKGDIIWIDFDPSAGKEIQKRRPGLVVSSYAFNKSTYFAVVCPITSTLKNYSTRFNLTSTSKIKGQVLISQL
KSLDYMERNSEFVEKISTNELEQINQLVSFVFAE

Download         Length: 345 bp

>T68122 NZ_CP017761:c2280810-2280466 [Marinilactibacillus sp. 15R]
ATGTCAGTTGATAAGTATATTCCCCATAAAGGAGATATTATCTGGATTGACTTTGATCCATCGGCTGGAAAAGAAATTCA
AAAAAGAAGACCTGGATTAGTGGTATCATCTTATGCATTTAATAAAAGCACTTATTTCGCAGTCGTCTGTCCTATTACTT
CTACTTTGAAAAACTACTCAACTCGATTCAATTTGACGAGCACATCAAAAATTAAAGGACAGGTATTGATTTCTCAATTA
AAATCACTTGATTATATGGAGAGAAATAGTGAGTTTGTTGAAAAAATATCTACAAATGAACTAGAACAAATCAACCAACT
CGTATCTTTTGTTTTTGCTGAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8597.91 Da        Isoelectric Point: 8.4302

>AT68122 WP_072695164.1 NZ_CP017761:c2281041-2280811 [Marinilactibacillus sp. 15R]
MLTTKLRKQGSSVVVTIPASEAKNLDMNVEYIVRTDKNGNISLIPKLDNPFKKAEPGEYYEKDVWADMKPAGKEVW

Download         Length: 231 bp

>AT68122 NZ_CP017761:c2281041-2280811 [Marinilactibacillus sp. 15R]
ATGTTAACAACAAAATTGCGGAAACAAGGAAGTTCCGTCGTGGTTACTATACCTGCTTCTGAAGCGAAAAATTTAGACAT
GAATGTAGAATATATTGTAAGAACGGATAAGAATGGAAACATATCCTTAATTCCCAAACTAGATAACCCATTCAAAAAGG
CGGAACCTGGAGAATATTATGAAAAAGATGTGTGGGCAGATATGAAACCGGCTGGAAAAGAGGTCTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4C165

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4C111

References