Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 672208..672703 Replicon chromosome
Accession NZ_CP017761
Organism Marinilactibacillus sp. 15R

Toxin (Protein)


Gene name relE Uniprot ID A0A1L4BX11
Locus tag BKP56_RS03315 Protein ID WP_072693699.1
Coordinates 672431..672703 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L4BX02
Locus tag BKP56_RS03310 Protein ID WP_072693698.1
Coordinates 672208..672429 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKP56_RS03295 667850..669229 + 1380 WP_072693696.1 hypothetical protein -
BKP56_RS03300 669257..670429 - 1173 WP_072693697.1 IS256 family transposase -
BKP56_RS03305 670880..672067 - 1188 WP_198033980.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
BKP56_RS03310 672208..672429 + 222 WP_072693698.1 ribbon-helix-helix protein, CopG family Antitoxin
BKP56_RS03315 672431..672703 + 273 WP_072693699.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKP56_RS03320 673359..674039 + 681 WP_002325565.1 IS6-like element IS1216 family transposase -
BKP56_RS03325 674081..674581 + 501 WP_072693700.1 hypothetical protein -
BKP56_RS03330 674794..675681 + 888 WP_072693701.1 DegV family protein -
BKP56_RS03335 676373..677089 + 717 WP_072693702.1 cytochrome c biogenesis CcdA family protein -
BKP56_RS03340 677191..677661 - 471 WP_072693703.1 signal peptidase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 672208..688611 16403
- inside IScluster/Tn - - 669257..674039 4782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-89)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.18 Da        Isoelectric Point: 10.1591

>T68121 WP_072693699.1 NZ_CP017761:672431-672703 [Marinilactibacillus sp. 15R]
MNSVYQVTFEKGAQKALKKMDKHQSLLIMGWIQKNLVNCTDPRKQGKGLTANRSGEWRYRIGDYRLIADINDETVTILML
EIGHRKDIYK

Download         Length: 273 bp

>T68121 NZ_CP017761:672431-672703 [Marinilactibacillus sp. 15R]
ATGAATTCAGTTTATCAAGTAACGTTTGAAAAAGGAGCACAAAAGGCTTTAAAAAAGATGGATAAACACCAGTCTCTTTT
AATTATGGGATGGATTCAAAAGAATCTAGTGAATTGTACAGATCCTAGGAAACAAGGAAAAGGACTGACTGCCAATCGTT
CAGGAGAATGGCGATATAGAATTGGAGATTATCGCTTAATTGCCGATATCAATGACGAGACAGTCACTATTTTAATGTTA
GAGATTGGCCACAGGAAAGATATTTATAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8404.39 Da        Isoelectric Point: 4.0414

>AT68121 WP_072693698.1 NZ_CP017761:672208-672429 [Marinilactibacillus sp. 15R]
MTVVSLRIDDQEDQLIKEYAKANNISVSALFRNSVLEKIEDEIDLSLYNQAMSEHKENPQSISFEDMLKELAD

Download         Length: 222 bp

>AT68121 NZ_CP017761:672208-672429 [Marinilactibacillus sp. 15R]
ATGACTGTAGTATCCCTAAGAATTGATGACCAAGAAGATCAACTAATCAAAGAATATGCTAAAGCTAATAATATTTCGGT
TTCAGCTTTATTTAGAAATTCTGTTTTAGAAAAAATCGAAGATGAAATTGATTTGAGTTTATATAACCAAGCTATGTCTG
AGCACAAAGAAAATCCGCAAAGTATTTCTTTTGAAGATATGCTAAAGGAGTTAGCGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4BX11

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4BX02

References