Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/YoeB-RelB |
Location | 3042920..3043449 | Replicon | chromosome |
Accession | NZ_CP017755 | ||
Organism | Cupriavidus malaysiensis strain USMAA1020 isolate pure |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A1D9H4T3 |
Locus tag | BKK80_RS32920 | Protein ID | WP_071018114.1 |
Coordinates | 3042920..3043189 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A1D9H5D1 |
Locus tag | BKK80_RS32925 | Protein ID | WP_071018112.1 |
Coordinates | 3043186..3043449 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BKK80_RS32900 | 3039384..3041054 | + | 1671 | WP_157903438.1 | amidohydrolase | - |
BKK80_RS32905 | 3041228..3042142 | + | 915 | WP_071072871.1 | phosphorylase | - |
BKK80_RS32910 | 3042234..3042541 | + | 308 | Protein_2632 | hypothetical protein | - |
BKK80_RS32915 | 3042585..3042851 | - | 267 | WP_071018116.1 | hypothetical protein | - |
BKK80_RS32920 | 3042920..3043189 | - | 270 | WP_071018114.1 | Txe/YoeB family addiction module toxin | Toxin |
BKK80_RS32925 | 3043186..3043449 | - | 264 | WP_071018112.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
BKK80_RS32930 | 3043525..3044244 | - | 720 | WP_071018110.1 | amino acid racemase | - |
BKK80_RS32935 | 3044533..3045012 | + | 480 | WP_071039019.1 | YiaA/YiaB family protein | - |
BKK80_RS32940 | 3045086..3046018 | - | 933 | WP_071073507.1 | LysR family transcriptional regulator | - |
BKK80_RS32945 | 3046072..3047409 | + | 1338 | WP_157903384.1 | MFS transporter | - |
BKK80_RS32950 | 3047448..3048422 | - | 975 | WP_071039023.1 | tripartite tricarboxylate transporter substrate binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10486.81 Da Isoelectric Point: 8.0151
>T68111 WP_071018114.1 NZ_CP017755:c3043189-3042920 [Cupriavidus malaysiensis]
MTRQLVFMPDAWDDYLYWQGQDRKTLKRINQLIQDTTRNPFDGVGKPEPLTGNLSGYWSRRIDNTNRLVYHANDDELTII
ACRLHYGAK
MTRQLVFMPDAWDDYLYWQGQDRKTLKRINQLIQDTTRNPFDGVGKPEPLTGNLSGYWSRRIDNTNRLVYHANDDELTII
ACRLHYGAK
Download Length: 270 bp
>T68111 NZ_CP017755:c3043189-3042920 [Cupriavidus malaysiensis]
ATGACGCGCCAGCTGGTCTTCATGCCCGACGCGTGGGATGACTATCTCTACTGGCAAGGACAGGACAGAAAGACGCTCAA
GCGAATCAATCAGCTCATCCAGGACACCACGCGTAACCCTTTCGATGGAGTCGGCAAGCCTGAGCCCCTGACGGGGAATC
TGTCCGGCTACTGGTCGCGCCGCATCGACAATACCAACCGTCTCGTTTATCACGCCAACGATGACGAGTTGACCATCATT
GCCTGTCGCCTGCACTACGGCGCCAAGTAG
ATGACGCGCCAGCTGGTCTTCATGCCCGACGCGTGGGATGACTATCTCTACTGGCAAGGACAGGACAGAAAGACGCTCAA
GCGAATCAATCAGCTCATCCAGGACACCACGCGTAACCCTTTCGATGGAGTCGGCAAGCCTGAGCCCCTGACGGGGAATC
TGTCCGGCTACTGGTCGCGCCGCATCGACAATACCAACCGTCTCGTTTATCACGCCAACGATGACGAGTTGACCATCATT
GCCTGTCGCCTGCACTACGGCGCCAAGTAG
Antitoxin
Download Length: 88 a.a. Molecular weight: 9935.13 Da Isoelectric Point: 4.8134
>AT68111 WP_071018112.1 NZ_CP017755:c3043449-3043186 [Cupriavidus malaysiensis]
MRTVHFSDARNNLKAVIDQAIADHDAILITRRDAPNAVIMSQEQYDSWMETMYLLSSPANAERLLRSIEQHRRGEGVERE
LIDPDAA
MRTVHFSDARNNLKAVIDQAIADHDAILITRRDAPNAVIMSQEQYDSWMETMYLLSSPANAERLLRSIEQHRRGEGVERE
LIDPDAA
Download Length: 264 bp
>AT68111 NZ_CP017755:c3043449-3043186 [Cupriavidus malaysiensis]
ATGCGCACCGTTCATTTCTCCGATGCCCGCAACAACCTGAAGGCCGTGATCGACCAGGCCATCGCCGATCACGATGCCAT
CCTGATCACACGGCGCGATGCGCCCAATGCCGTGATCATGTCGCAGGAACAGTACGACAGCTGGATGGAAACCATGTACC
TGCTCAGTTCGCCGGCCAATGCGGAGCGCTTGCTGCGCTCCATCGAGCAGCATCGCCGGGGCGAGGGGGTGGAGCGTGAG
TTGATCGATCCGGACGCGGCATGA
ATGCGCACCGTTCATTTCTCCGATGCCCGCAACAACCTGAAGGCCGTGATCGACCAGGCCATCGCCGATCACGATGCCAT
CCTGATCACACGGCGCGATGCGCCCAATGCCGTGATCATGTCGCAGGAACAGTACGACAGCTGGATGGAAACCATGTACC
TGCTCAGTTCGCCGGCCAATGCGGAGCGCTTGCTGCGCTCCATCGAGCAGCATCGCCGGGGCGAGGGGGTGGAGCGTGAG
TTGATCGATCCGGACGCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H4T3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H5D1 |