Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1225342..1225979 Replicon chromosome
Accession NZ_CP017755
Organism Cupriavidus malaysiensis strain USMAA1020 isolate pure

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D9H853
Locus tag BKK80_RS25060 Protein ID WP_071021112.1
Coordinates 1225342..1225743 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1D9H848
Locus tag BKK80_RS25065 Protein ID WP_071021111.1
Coordinates 1225743..1225979 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK80_RS25045 1221468..1222742 - 1275 WP_071039726.1 cytochrome P450 -
BKK80_RS25050 1223260..1224801 + 1542 WP_071021117.1 MCP four helix bundle domain-containing protein -
BKK80_RS25055 1224853..1225221 - 369 WP_071021114.1 cytochrome c family protein -
BKK80_RS25060 1225342..1225743 - 402 WP_071021112.1 type II toxin-antitoxin system VapC family toxin Toxin
BKK80_RS25065 1225743..1225979 - 237 WP_071021111.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKK80_RS25070 1226242..1227198 + 957 Protein_1040 translesion DNA synthesis-associated protein ImuA -
BKK80_RS37240 1227134..1228681 + 1548 WP_071073293.1 DNA polymerase Y family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15117.40 Da        Isoelectric Point: 6.0839

>T68110 WP_071021112.1 NZ_CP017755:c1225743-1225342 [Cupriavidus malaysiensis]
MPRFMLDTNMCIYLMRDQPEQVARRFAQCYVGDVVMSAITYAELEYGVAVSADPARERLHLASLVEDIPVMPFEAAAARA
YGPVRQATRERRKDHLDKLIAAHALALDLVLVTNNERDFAHYPGLRLENWLQG

Download         Length: 402 bp

>T68110 NZ_CP017755:c1225743-1225342 [Cupriavidus malaysiensis]
ATGCCGCGCTTCATGCTCGACACCAATATGTGCATCTACCTGATGCGGGACCAGCCCGAGCAGGTGGCGAGACGCTTTGC
GCAATGCTATGTCGGTGACGTGGTGATGTCTGCCATCACCTATGCCGAACTGGAATACGGCGTCGCCGTGTCGGCCGACC
CCGCCCGGGAACGCCTGCACCTCGCCTCGCTGGTCGAGGACATTCCGGTGATGCCCTTCGAGGCGGCCGCGGCGCGGGCC
TACGGCCCCGTCCGGCAGGCGACGCGCGAGCGCAGGAAGGACCATCTGGACAAGCTGATCGCAGCCCATGCGCTGGCACT
GGACCTGGTCCTGGTCACCAACAACGAAAGAGACTTCGCGCACTATCCGGGCCTGCGGCTGGAGAACTGGTTGCAGGGAT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8937.04 Da        Isoelectric Point: 5.1679

>AT68110 WP_071021111.1 NZ_CP017755:c1225979-1225743 [Cupriavidus malaysiensis]
MHTTRLFKNGNSQAVRIPADLAYDRTDVELEIERIGDEIRIRPARRPLAGVLEKFAKFGPDFMAEGRDEHGQDEREAL

Download         Length: 237 bp

>AT68110 NZ_CP017755:c1225979-1225743 [Cupriavidus malaysiensis]
ATGCACACCACACGCCTCTTCAAGAACGGCAACTCGCAGGCCGTGCGTATTCCGGCCGACCTGGCCTACGACCGCACCGA
CGTGGAACTGGAGATCGAGCGCATCGGCGACGAGATCCGCATCCGCCCGGCGCGCCGGCCGCTGGCCGGGGTTCTGGAGA
AGTTCGCGAAATTCGGCCCGGACTTCATGGCCGAGGGCCGCGACGAGCACGGCCAGGACGAGCGCGAGGCCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9H853

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9H848

References