Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-MazE |
Location | 543949..544544 | Replicon | chromosome |
Accession | NZ_CP017755 | ||
Organism | Cupriavidus malaysiensis strain USMAA1020 isolate pure |
Toxin (Protein)
Gene name | chpB | Uniprot ID | A0A1D9H6T2 |
Locus tag | BKK80_RS22295 | Protein ID | WP_071039392.1 |
Coordinates | 544194..544544 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | A0A1D9H6K6 |
Locus tag | BKK80_RS22290 | Protein ID | WP_071039391.1 |
Coordinates | 543949..544200 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BKK80_RS22280 | 541808..543046 | - | 1239 | WP_071016974.1 | type II toxin-antitoxin system HipA family toxin | - |
BKK80_RS22285 | 543043..543405 | - | 363 | WP_071039390.1 | helix-turn-helix transcriptional regulator | - |
BKK80_RS22290 | 543949..544200 | + | 252 | WP_071039391.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
BKK80_RS22295 | 544194..544544 | + | 351 | WP_071039392.1 | type II toxin-antitoxin system ChpB family toxin | Toxin |
BKK80_RS36600 | 544510..544632 | + | 123 | WP_157903308.1 | DUF1484 family protein | - |
BKK80_RS22300 | 544706..545119 | - | 414 | WP_157903309.1 | cupin domain-containing protein | - |
BKK80_RS22305 | 545200..546027 | - | 828 | WP_071071334.1 | AraC family transcriptional regulator | - |
BKK80_RS22310 | 546130..546546 | - | 417 | WP_071071336.1 | NUDIX domain-containing protein | - |
BKK80_RS36605 | 546670..547119 | - | 450 | WP_157903310.1 | hypothetical protein | - |
BKK80_RS36610 | 547179..547997 | - | 819 | WP_157903311.1 | hypothetical protein | - |
BKK80_RS36615 | 548120..548938 | - | 819 | WP_157903312.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 509204..553041 | 43837 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12344.15 Da Isoelectric Point: 6.3482
>T68108 WP_071039392.1 NZ_CP017755:544194-544544 [Cupriavidus malaysiensis]
MVRRAKFDRGDIVRVSLNPTEGREQQGDFRPALVLSPAAFNALGVALVAPITQGGDFARFAGFAVPLSGAGTETQGVALV
NMVRTLDLEARGARKIERAPAEVVEDALARLQTILD
MVRRAKFDRGDIVRVSLNPTEGREQQGDFRPALVLSPAAFNALGVALVAPITQGGDFARFAGFAVPLSGAGTETQGVALV
NMVRTLDLEARGARKIERAPAEVVEDALARLQTILD
Download Length: 351 bp
>T68108 NZ_CP017755:544194-544544 [Cupriavidus malaysiensis]
ATGGTGAGGCGCGCGAAGTTCGACCGGGGCGACATTGTGCGGGTGAGCCTGAACCCAACGGAGGGGCGTGAGCAGCAAGG
GGATTTCCGTCCCGCGCTCGTGCTGTCACCGGCAGCATTCAACGCTCTGGGTGTTGCCCTGGTGGCACCGATTACGCAGG
GCGGCGATTTCGCTCGATTCGCCGGATTTGCCGTACCGTTGTCCGGGGCGGGCACGGAGACTCAAGGCGTCGCGCTGGTG
AACATGGTGCGCACTCTGGATCTTGAGGCTCGCGGTGCGAGGAAGATCGAACGGGCACCTGCCGAGGTCGTGGAAGATGC
GCTCGCCCGTCTTCAAACCATCCTGGATTAG
ATGGTGAGGCGCGCGAAGTTCGACCGGGGCGACATTGTGCGGGTGAGCCTGAACCCAACGGAGGGGCGTGAGCAGCAAGG
GGATTTCCGTCCCGCGCTCGTGCTGTCACCGGCAGCATTCAACGCTCTGGGTGTTGCCCTGGTGGCACCGATTACGCAGG
GCGGCGATTTCGCTCGATTCGCCGGATTTGCCGTACCGTTGTCCGGGGCGGGCACGGAGACTCAAGGCGTCGCGCTGGTG
AACATGGTGCGCACTCTGGATCTTGAGGCTCGCGGTGCGAGGAAGATCGAACGGGCACCTGCCGAGGTCGTGGAAGATGC
GCTCGCCCGTCTTCAAACCATCCTGGATTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9141.53 Da Isoelectric Point: 5.8125
>AT68108 WP_071039391.1 NZ_CP017755:543949-544200 [Cupriavidus malaysiensis]
MELSIQKWGNSAAVRLPTTLLEQLKVALGDKLSVEVRPDGVMLKPARHKYSLDELLAQCDSKAPTPEGLDDWSGAKPVGR
EVW
MELSIQKWGNSAAVRLPTTLLEQLKVALGDKLSVEVRPDGVMLKPARHKYSLDELLAQCDSKAPTPEGLDDWSGAKPVGR
EVW
Download Length: 252 bp
>AT68108 NZ_CP017755:543949-544200 [Cupriavidus malaysiensis]
ATGGAACTGTCGATTCAGAAATGGGGTAACAGCGCGGCCGTGCGCCTGCCCACGACCTTGCTTGAACAACTCAAGGTGGC
GTTGGGCGACAAACTGTCCGTGGAGGTGCGTCCGGATGGTGTCATGCTTAAACCAGCCAGGCACAAGTATTCACTCGATG
AACTGCTTGCGCAGTGCGACTCCAAGGCGCCGACGCCTGAAGGGCTGGATGATTGGAGCGGGGCTAAGCCGGTTGGGCGC
GAAGTATGGTGA
ATGGAACTGTCGATTCAGAAATGGGGTAACAGCGCGGCCGTGCGCCTGCCCACGACCTTGCTTGAACAACTCAAGGTGGC
GTTGGGCGACAAACTGTCCGTGGAGGTGCGTCCGGATGGTGTCATGCTTAAACCAGCCAGGCACAAGTATTCACTCGATG
AACTGCTTGCGCAGTGCGACTCCAAGGCGCCGACGCCTGAAGGGCTGGATGATTGGAGCGGGGCTAAGCCGGTTGGGCGC
GAAGTATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H6T2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H6K6 |