Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 375722..376758 | Replicon | chromosome |
| Accession | NZ_CP017755 | ||
| Organism | Cupriavidus malaysiensis strain USMAA1020 isolate pure | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | BKK80_RS21570 | Protein ID | WP_071071169.1 |
| Coordinates | 375722..376297 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A1D9H662 |
| Locus tag | BKK80_RS21575 | Protein ID | WP_071017164.1 |
| Coordinates | 376294..376758 (-) | Length | 155 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BKK80_RS21545 | 371010..371432 | - | 423 | Protein_320 | cation:dicarboxylase symporter family transporter | - |
| BKK80_RS21550 | 371620..372708 | - | 1089 | WP_071071163.1 | tartrate dehydrogenase | - |
| BKK80_RS21555 | 372885..373808 | + | 924 | WP_071071165.1 | LysR family transcriptional regulator | - |
| BKK80_RS36545 | 373869..374018 | + | 150 | WP_157903292.1 | hypothetical protein | - |
| BKK80_RS21560 | 374050..374736 | - | 687 | WP_071039286.1 | signal peptidase I | - |
| BKK80_RS21565 | 374916..375533 | + | 618 | WP_071071167.1 | J domain-containing protein | - |
| BKK80_RS21570 | 375722..376297 | - | 576 | WP_071071169.1 | PIN domain-containing protein | Toxin |
| BKK80_RS21575 | 376294..376758 | - | 465 | WP_071017164.1 | helix-turn-helix domain-containing protein | Antitoxin |
| BKK80_RS21580 | 376967..378115 | - | 1149 | WP_157903293.1 | acyltransferase | - |
| BKK80_RS21585 | 378123..379001 | - | 879 | WP_084545679.1 | class D beta-lactamase | - |
| BKK80_RS21590 | 379082..380824 | - | 1743 | WP_157903294.1 | serine hydrolase | - |
| BKK80_RS21595 | 380821..381210 | - | 390 | WP_071017158.1 | BlaI/MecI/CopY family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 375722..385832 | 10110 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21863.97 Da Isoelectric Point: 5.2922
>T68107 WP_071071169.1 NZ_CP017755:c376297-375722 [Cupriavidus malaysiensis]
MRHSPFTALYDACVLYPAPLRDFLMWLGLSGRFRARWSPQIHDEWKRNLLANREDLTREQLDRTSDLMDRAIPDALVLDY
EALAVELWLPDPDDRHVLAAAIRCGASVIVTFNRKDFPDDALAPFGIEARHPDEFIDNLFDLDAAAVVAAARQQRAQLKH
PPMDVDRYLDVLQRQGLLQTVKGLGQYRSIL
MRHSPFTALYDACVLYPAPLRDFLMWLGLSGRFRARWSPQIHDEWKRNLLANREDLTREQLDRTSDLMDRAIPDALVLDY
EALAVELWLPDPDDRHVLAAAIRCGASVIVTFNRKDFPDDALAPFGIEARHPDEFIDNLFDLDAAAVVAAARQQRAQLKH
PPMDVDRYLDVLQRQGLLQTVKGLGQYRSIL
Download Length: 576 bp
>T68107 NZ_CP017755:c376297-375722 [Cupriavidus malaysiensis]
ATGAGGCATTCGCCATTCACAGCCCTGTATGACGCTTGCGTGCTGTATCCAGCGCCACTGCGCGACTTTCTCATGTGGCT
GGGCCTGTCGGGGCGGTTCCGTGCACGGTGGAGTCCGCAGATCCACGACGAATGGAAGCGCAATCTGCTGGCTAACCGCG
AAGACCTGACGCGCGAGCAACTGGATCGCACATCGGACCTGATGGATCGCGCCATCCCTGATGCCTTGGTCCTTGACTAC
GAGGCACTTGCCGTCGAACTATGGTTACCGGACCCAGACGACCGGCACGTACTCGCCGCCGCCATTCGTTGCGGTGCCAG
CGTCATCGTCACCTTCAACCGGAAAGACTTTCCGGACGACGCATTGGCACCGTTCGGCATCGAGGCCCGGCACCCCGACG
AATTCATCGACAACCTGTTCGACCTGGATGCGGCCGCTGTCGTTGCCGCCGCCCGGCAGCAGCGCGCGCAGCTCAAGCAT
CCGCCCATGGATGTCGACCGCTACCTCGACGTGCTGCAACGCCAGGGCCTGCTGCAAACCGTCAAGGGCCTGGGCCAATA
CCGTTCCATCCTGTAG
ATGAGGCATTCGCCATTCACAGCCCTGTATGACGCTTGCGTGCTGTATCCAGCGCCACTGCGCGACTTTCTCATGTGGCT
GGGCCTGTCGGGGCGGTTCCGTGCACGGTGGAGTCCGCAGATCCACGACGAATGGAAGCGCAATCTGCTGGCTAACCGCG
AAGACCTGACGCGCGAGCAACTGGATCGCACATCGGACCTGATGGATCGCGCCATCCCTGATGCCTTGGTCCTTGACTAC
GAGGCACTTGCCGTCGAACTATGGTTACCGGACCCAGACGACCGGCACGTACTCGCCGCCGCCATTCGTTGCGGTGCCAG
CGTCATCGTCACCTTCAACCGGAAAGACTTTCCGGACGACGCATTGGCACCGTTCGGCATCGAGGCCCGGCACCCCGACG
AATTCATCGACAACCTGTTCGACCTGGATGCGGCCGCTGTCGTTGCCGCCGCCCGGCAGCAGCGCGCGCAGCTCAAGCAT
CCGCCCATGGATGTCGACCGCTACCTCGACGTGCTGCAACGCCAGGGCCTGCTGCAAACCGTCAAGGGCCTGGGCCAATA
CCGTTCCATCCTGTAG
Antitoxin
Download Length: 155 a.a. Molecular weight: 16946.27 Da Isoelectric Point: 6.4928
>AT68107 WP_071017164.1 NZ_CP017755:c376758-376294 [Cupriavidus malaysiensis]
VTAAYSRVTLPVEREVQAAVQGQRALAAYLATQVETQRIQIFDDKNQAHQVELPTSALRLLVDILAELAGGNAVKVVPVH
AELTTQEAADLLNVSRPHLVKLLEDGALPFHRAGKHRRVRFSDLMQFKAARDQASEQAMAELAHQAQVSDMGYE
VTAAYSRVTLPVEREVQAAVQGQRALAAYLATQVETQRIQIFDDKNQAHQVELPTSALRLLVDILAELAGGNAVKVVPVH
AELTTQEAADLLNVSRPHLVKLLEDGALPFHRAGKHRRVRFSDLMQFKAARDQASEQAMAELAHQAQVSDMGYE
Download Length: 465 bp
>AT68107 NZ_CP017755:c376758-376294 [Cupriavidus malaysiensis]
GTGACCGCCGCCTATTCGAGAGTAACGCTACCCGTGGAACGGGAAGTGCAGGCTGCCGTGCAAGGTCAACGCGCCTTGGC
GGCTTATCTGGCCACCCAGGTCGAGACCCAGCGCATCCAGATCTTCGATGACAAGAATCAAGCTCATCAGGTGGAGCTGC
CAACATCGGCGCTCCGCCTGCTGGTGGACATCCTGGCCGAACTGGCCGGCGGCAATGCCGTCAAGGTCGTGCCTGTTCAT
GCCGAGTTGACCACGCAGGAAGCGGCCGACCTGCTCAACGTCTCCCGGCCGCACCTGGTCAAGTTGCTGGAAGACGGCGC
GCTGCCGTTCCATCGGGCTGGCAAGCACCGCCGCGTGCGCTTTTCGGACCTGATGCAGTTCAAGGCCGCGCGCGATCAGG
CCAGTGAGCAAGCCATGGCCGAGTTGGCGCATCAAGCCCAGGTGTCTGACATGGGTTACGAATGA
GTGACCGCCGCCTATTCGAGAGTAACGCTACCCGTGGAACGGGAAGTGCAGGCTGCCGTGCAAGGTCAACGCGCCTTGGC
GGCTTATCTGGCCACCCAGGTCGAGACCCAGCGCATCCAGATCTTCGATGACAAGAATCAAGCTCATCAGGTGGAGCTGC
CAACATCGGCGCTCCGCCTGCTGGTGGACATCCTGGCCGAACTGGCCGGCGGCAATGCCGTCAAGGTCGTGCCTGTTCAT
GCCGAGTTGACCACGCAGGAAGCGGCCGACCTGCTCAACGTCTCCCGGCCGCACCTGGTCAAGTTGCTGGAAGACGGCGC
GCTGCCGTTCCATCGGGCTGGCAAGCACCGCCGCGTGCGCTTTTCGGACCTGATGCAGTTCAAGGCCGCGCGCGATCAGG
CCAGTGAGCAAGCCATGGCCGAGTTGGCGCATCAAGCCCAGGTGTCTGACATGGGTTACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|