Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 304021..305755 | Replicon | chromosome |
Accession | NZ_CP017755 | ||
Organism | Cupriavidus malaysiensis strain USMAA1020 isolate pure |
Toxin (Protein)
Gene name | doc | Uniprot ID | A0A1D9HB80 |
Locus tag | BKK80_RS21250 | Protein ID | WP_071040378.1 |
Coordinates | 304021..304887 (+) | Length | 289 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A1D9H639 |
Locus tag | BKK80_RS21255 | Protein ID | WP_071039249.1 |
Coordinates | 304925..305755 (+) | Length | 277 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BKK80_RS21230 | 301218..301523 | + | 306 | WP_071017289.1 | hypothetical protein | - |
BKK80_RS21235 | 301574..302629 | + | 1056 | WP_071073170.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
BKK80_RS21240 | 302622..303392 | + | 771 | WP_071039248.1 | SDR family oxidoreductase | - |
BKK80_RS21245 | 303411..303950 | + | 540 | WP_071017285.1 | cupin domain-containing protein | - |
BKK80_RS21250 | 304021..304887 | + | 867 | WP_071040378.1 | alpha/beta hydrolase | Toxin |
BKK80_RS21255 | 304925..305755 | + | 831 | WP_071039249.1 | IclR family transcriptional regulator | Antitoxin |
BKK80_RS21260 | 305772..306575 | + | 804 | WP_071071091.1 | SDR family oxidoreductase | - |
BKK80_RS21265 | 306568..308295 | + | 1728 | WP_071071094.1 | thiamine pyrophosphate-binding protein | - |
BKK80_RS21270 | 308312..309112 | + | 801 | WP_071071096.1 | aspartate dehydrogenase | - |
BKK80_RS21275 | 309156..310631 | + | 1476 | WP_071039253.1 | aldehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 289 a.a. Molecular weight: 29552.00 Da Isoelectric Point: 8.4856
>T68106 WP_071040378.1 NZ_CP017755:304021-304887 [Cupriavidus malaysiensis]
MLAELDAGFAERTAVLADGARVAYRSGGRQGPLVVLLHGISSGAASWLPCASLLAAQARVLAWDAPGYGASAALAQPAPR
ASDYAARLAGLLEALALRPDVIVGHSLGALMAAAFVAQARPALLPSRLLLLSPAQGYGAPGQQEQAAQVSAQRLQALAQL
GVEGLAERGPQRLLSAAADAGARDWVRWNMRRLNVDGYRQAVAMLCGDAIEPYLQRRAAGVDARVACGGADVVTTPAASE
ALAQRLGLPFGLVPDAGHVCYIEQPQALARMLRGLLPAAAAPGAAVSH
MLAELDAGFAERTAVLADGARVAYRSGGRQGPLVVLLHGISSGAASWLPCASLLAAQARVLAWDAPGYGASAALAQPAPR
ASDYAARLAGLLEALALRPDVIVGHSLGALMAAAFVAQARPALLPSRLLLLSPAQGYGAPGQQEQAAQVSAQRLQALAQL
GVEGLAERGPQRLLSAAADAGARDWVRWNMRRLNVDGYRQAVAMLCGDAIEPYLQRRAAGVDARVACGGADVVTTPAASE
ALAQRLGLPFGLVPDAGHVCYIEQPQALARMLRGLLPAAAAPGAAVSH
Download Length: 867 bp
>T68106 NZ_CP017755:304021-304887 [Cupriavidus malaysiensis]
CTGCTCGCCGAACTGGACGCGGGCTTCGCCGAGCGCACGGCCGTGCTGGCCGACGGCGCCCGCGTGGCCTACCGCAGCGG
CGGCAGGCAGGGCCCGCTGGTGGTGCTGCTGCACGGCATCAGCTCCGGCGCGGCCTCCTGGCTGCCGTGCGCCAGCCTGC
TGGCGGCGCAGGCGCGCGTGCTGGCATGGGACGCGCCCGGCTACGGCGCTTCCGCCGCGCTGGCGCAACCGGCGCCGCGC
GCCTCGGACTATGCGGCGCGGCTGGCGGGTTTGCTGGAGGCGCTGGCGCTGCGTCCCGACGTCATCGTCGGCCACTCGCT
GGGCGCGCTGATGGCCGCGGCCTTCGTCGCGCAGGCGCGTCCCGCGCTGCTGCCGTCGCGGCTGCTGCTGCTCAGCCCGG
CGCAGGGCTACGGCGCGCCCGGCCAGCAGGAACAAGCGGCACAGGTGTCGGCGCAGCGGCTGCAGGCGCTGGCGCAGCTC
GGCGTGGAAGGCCTGGCCGAGCGCGGTCCGCAGCGCCTGCTGAGCGCGGCCGCCGATGCCGGCGCGCGCGACTGGGTGCG
CTGGAACATGCGGCGCCTGAACGTGGACGGTTACCGCCAGGCGGTGGCCATGCTGTGCGGCGATGCCATCGAGCCCTACC
TGCAGCGGCGAGCCGCCGGGGTGGACGCGCGGGTGGCCTGCGGCGGCGCGGACGTGGTCACCACGCCGGCGGCGAGCGAG
GCGCTGGCACAGCGTCTGGGCCTGCCTTTCGGCCTGGTGCCCGATGCCGGTCATGTGTGTTATATCGAGCAGCCACAGGC
ACTGGCGCGCATGCTGCGCGGCCTGCTGCCCGCCGCGGCCGCTCCCGGCGCCGCCGTGTCACACTGA
CTGCTCGCCGAACTGGACGCGGGCTTCGCCGAGCGCACGGCCGTGCTGGCCGACGGCGCCCGCGTGGCCTACCGCAGCGG
CGGCAGGCAGGGCCCGCTGGTGGTGCTGCTGCACGGCATCAGCTCCGGCGCGGCCTCCTGGCTGCCGTGCGCCAGCCTGC
TGGCGGCGCAGGCGCGCGTGCTGGCATGGGACGCGCCCGGCTACGGCGCTTCCGCCGCGCTGGCGCAACCGGCGCCGCGC
GCCTCGGACTATGCGGCGCGGCTGGCGGGTTTGCTGGAGGCGCTGGCGCTGCGTCCCGACGTCATCGTCGGCCACTCGCT
GGGCGCGCTGATGGCCGCGGCCTTCGTCGCGCAGGCGCGTCCCGCGCTGCTGCCGTCGCGGCTGCTGCTGCTCAGCCCGG
CGCAGGGCTACGGCGCGCCCGGCCAGCAGGAACAAGCGGCACAGGTGTCGGCGCAGCGGCTGCAGGCGCTGGCGCAGCTC
GGCGTGGAAGGCCTGGCCGAGCGCGGTCCGCAGCGCCTGCTGAGCGCGGCCGCCGATGCCGGCGCGCGCGACTGGGTGCG
CTGGAACATGCGGCGCCTGAACGTGGACGGTTACCGCCAGGCGGTGGCCATGCTGTGCGGCGATGCCATCGAGCCCTACC
TGCAGCGGCGAGCCGCCGGGGTGGACGCGCGGGTGGCCTGCGGCGGCGCGGACGTGGTCACCACGCCGGCGGCGAGCGAG
GCGCTGGCACAGCGTCTGGGCCTGCCTTTCGGCCTGGTGCCCGATGCCGGTCATGTGTGTTATATCGAGCAGCCACAGGC
ACTGGCGCGCATGCTGCGCGGCCTGCTGCCCGCCGCGGCCGCTCCCGGCGCCGCCGTGTCACACTGA
Antitoxin
Download Length: 277 a.a. Molecular weight: 30982.59 Da Isoelectric Point: 6.0599
>AT68106 WP_071039249.1 NZ_CP017755:304925-305755 [Cupriavidus malaysiensis]
MSKATLPEDLQEKYIVPGLERGLRLLCEFSRKDSTLSAAELARRLQVPRSTVFRLLTTLEMMGFVERTDGGREFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIHYPCNLVVRDGRSIVYVAKSVAPTPFASSVNVGTRLPAHATVLGRVLLEDLS
LAELRELYPESQLEVFSESTPRTVEQLFEMVQHDRQRGYVLQEGFFEASISTIAAPVRDRSGKVAAAMGATIPASRIDPE
QLGPMVEQVRHAADELSRLLDYRPAAEHKVVNLYRE
MSKATLPEDLQEKYIVPGLERGLRLLCEFSRKDSTLSAAELARRLQVPRSTVFRLLTTLEMMGFVERTDGGREFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIHYPCNLVVRDGRSIVYVAKSVAPTPFASSVNVGTRLPAHATVLGRVLLEDLS
LAELRELYPESQLEVFSESTPRTVEQLFEMVQHDRQRGYVLQEGFFEASISTIAAPVRDRSGKVAAAMGATIPASRIDPE
QLGPMVEQVRHAADELSRLLDYRPAAEHKVVNLYRE
Download Length: 831 bp
>AT68106 NZ_CP017755:304925-305755 [Cupriavidus malaysiensis]
ATGAGCAAAGCCACCCTGCCCGAAGACCTCCAGGAAAAGTACATCGTGCCGGGCCTGGAGCGCGGACTGCGGCTGCTGTG
CGAATTCAGCCGCAAGGACAGCACGCTGTCGGCGGCCGAACTGGCGCGCCGGCTGCAGGTGCCCCGCTCCACGGTGTTCC
GTTTGCTGACCACGCTGGAGATGATGGGTTTCGTCGAGCGCACCGACGGCGGGCGCGAGTTCCGCCTCGGCATGGCCGTG
CTGCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAACTGACCGAGCTGGGCCGGCCGCTGCTCGACCGCCTGCGCGACGA
CATCCACTACCCGTGCAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTCGCCAAGTCGGTGGCGCCGACGCCGT
TCGCCAGCTCCGTCAACGTGGGCACGCGCCTGCCGGCGCACGCCACCGTGCTCGGCCGCGTGCTGCTGGAAGACCTGTCG
CTGGCCGAACTGCGCGAGCTCTATCCGGAGTCGCAGCTCGAGGTGTTCTCGGAAAGCACCCCGCGCACCGTCGAACAGCT
GTTCGAGATGGTGCAGCACGACCGCCAGCGCGGCTACGTGCTGCAGGAAGGCTTCTTCGAAGCGAGCATCTCCACCATCG
CGGCGCCGGTGCGCGATCGCAGCGGCAAGGTGGCGGCGGCGATGGGCGCGACGATTCCGGCCTCGCGCATCGACCCGGAG
CAGCTCGGCCCGATGGTGGAACAGGTCCGTCATGCGGCGGACGAGCTCTCGCGCCTGCTGGACTACCGTCCGGCGGCGGA
GCACAAGGTAGTCAACTTATACCGAGAATGA
ATGAGCAAAGCCACCCTGCCCGAAGACCTCCAGGAAAAGTACATCGTGCCGGGCCTGGAGCGCGGACTGCGGCTGCTGTG
CGAATTCAGCCGCAAGGACAGCACGCTGTCGGCGGCCGAACTGGCGCGCCGGCTGCAGGTGCCCCGCTCCACGGTGTTCC
GTTTGCTGACCACGCTGGAGATGATGGGTTTCGTCGAGCGCACCGACGGCGGGCGCGAGTTCCGCCTCGGCATGGCCGTG
CTGCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAACTGACCGAGCTGGGCCGGCCGCTGCTCGACCGCCTGCGCGACGA
CATCCACTACCCGTGCAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTCGCCAAGTCGGTGGCGCCGACGCCGT
TCGCCAGCTCCGTCAACGTGGGCACGCGCCTGCCGGCGCACGCCACCGTGCTCGGCCGCGTGCTGCTGGAAGACCTGTCG
CTGGCCGAACTGCGCGAGCTCTATCCGGAGTCGCAGCTCGAGGTGTTCTCGGAAAGCACCCCGCGCACCGTCGAACAGCT
GTTCGAGATGGTGCAGCACGACCGCCAGCGCGGCTACGTGCTGCAGGAAGGCTTCTTCGAAGCGAGCATCTCCACCATCG
CGGCGCCGGTGCGCGATCGCAGCGGCAAGGTGGCGGCGGCGATGGGCGCGACGATTCCGGCCTCGCGCATCGACCCGGAG
CAGCTCGGCCCGATGGTGGAACAGGTCCGTCATGCGGCGGACGAGCTCTCGCGCCTGCTGGACTACCGTCCGGCGGCGGA
GCACAAGGTAGTCAACTTATACCGAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9HB80 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H639 |