Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1280322..1280890 Replicon chromosome
Accession NZ_CP017754
Organism Cupriavidus malaysiensis strain USMAA1020 isolate pure

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag BKK80_RS05570 Protein ID WP_071070708.1
Coordinates 1280609..1280890 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag BKK80_RS35365 Protein ID WP_084545491.1
Coordinates 1280322..1280609 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK80_RS36245 1275542..1276345 + 804 WP_157903160.1 hypothetical protein -
BKK80_RS05550 1276706..1276918 + 213 WP_071011411.1 hypothetical protein -
BKK80_RS05555 1277007..1278392 - 1386 WP_071068697.1 phosphomannomutase/phosphoglucomutase -
BKK80_RS05560 1278539..1278904 - 366 WP_071068698.1 hypothetical protein -
BKK80_RS05565 1279230..1279526 - 297 WP_071068699.1 hypothetical protein -
BKK80_RS35365 1280322..1280609 + 288 WP_084545491.1 hypothetical protein Antitoxin
BKK80_RS05570 1280609..1280890 + 282 WP_071070708.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BKK80_RS05575 1281096..1281518 - 423 WP_071011419.1 Lrp/AsnC family transcriptional regulator -
BKK80_RS05580 1281762..1282658 + 897 WP_071068700.1 amidinotransferase -
BKK80_RS05585 1282715..1283848 + 1134 WP_084545492.1 ornithine cyclodeaminase -
BKK80_RS05590 1284306..1285076 + 771 WP_071068701.1 SDR family oxidoreductase -
BKK80_RS05595 1285216..1285821 - 606 WP_071037400.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 5.6032

>T68105 WP_071070708.1 NZ_CP017754:1280609-1280890 [Cupriavidus malaysiensis]
MTLFWTPEALQDREDIYDYIEVENPAAALGLDAMIAEKAGRLAEHPALGRPGRVGGTRELIAHENYLLIYDIVGGQVRVL
RVMHASRRWPPQA

Download         Length: 282 bp

>T68105 NZ_CP017754:1280609-1280890 [Cupriavidus malaysiensis]
ATGACGCTGTTCTGGACCCCCGAGGCTCTCCAGGACCGTGAAGACATCTACGACTATATCGAAGTCGAAAACCCGGCCGC
TGCGCTGGGACTCGACGCAATGATTGCAGAGAAGGCCGGCCGTTTAGCCGAGCACCCAGCGCTTGGCCGGCCTGGCCGTG
TGGGCGGCACTCGCGAACTCATAGCACACGAGAATTATCTTCTGATCTATGACATCGTTGGCGGGCAAGTGCGGGTGCTT
CGCGTGATGCACGCATCTCGTAGGTGGCCGCCGCAAGCGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10710.83 Da        Isoelectric Point: 7.2075

>AT68105 WP_084545491.1 NZ_CP017754:1280322-1280609 [Cupriavidus malaysiensis]
VSDATFTFRVDDGLKDAFSAAAKARDRSGAQLLRDFMRDFVRQQQEAAEHDAWFRHQVEIGRASADAGNLIPASEVEAKF
EARREATRRRLKGES

Download         Length: 288 bp

>AT68105 NZ_CP017754:1280322-1280609 [Cupriavidus malaysiensis]
GTGAGCGATGCAACCTTCACTTTCCGGGTCGATGATGGGTTGAAAGATGCATTCTCGGCAGCCGCAAAGGCGCGTGATCG
CAGTGGTGCGCAACTTCTGCGCGACTTCATGCGTGATTTCGTGCGGCAGCAGCAGGAAGCGGCCGAGCATGATGCTTGGT
TTCGCCATCAGGTGGAAATCGGCCGCGCCTCGGCCGACGCTGGCAATCTAATTCCAGCATCGGAGGTCGAAGCCAAGTTC
GAAGCAAGGAGAGAGGCGACTCGCCGCCGGCTCAAGGGTGAGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References