68104

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 381605..383217 Replicon chromosome
Accession NZ_CP017754
Organism Cupriavidus malaysiensis strain USMAA1020 isolate pure

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BKK80_RS01570 Protein ID WP_071068490.1
Coordinates 381877..383217 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1D9H2X1
Locus tag BKK80_RS01565 Protein ID WP_071015926.1
Coordinates 381605..381871 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK80_RS01540 377729..378472 + 744 WP_071068488.1 3-oxoacid CoA-transferase subunit A -
BKK80_RS01545 378478..379140 + 663 WP_071010570.1 3-oxoacid CoA-transferase subunit B -
BKK80_RS01550 379301..380587 + 1287 WP_071068489.1 MFS transporter -
BKK80_RS01555 380681..381019 + 339 WP_071010572.1 4-methylmuconolactone methylisomerase -
BKK80_RS01560 381140..381415 + 276 WP_071010573.1 muconolactone Delta-isomerase -
BKK80_RS01565 381605..381871 + 267 WP_071015926.1 helix-turn-helix domain-containing protein Antitoxin
BKK80_RS01570 381877..383217 + 1341 WP_071068490.1 type II toxin-antitoxin system HipA family toxin Toxin
BKK80_RS01575 383539..383775 - 237 WP_071068491.1 hypothetical protein -
BKK80_RS01580 383934..384809 - 876 WP_157903141.1 anti-sigma factor -
BKK80_RS01585 384799..385401 - 603 WP_071037678.1 RNA polymerase sigma factor -
BKK80_RS01590 385522..386043 - 522 WP_084545449.1 dethiobiotin synthetase -
BKK80_RS01595 386040..386648 - 609 WP_205683715.1 lecithin retinol acyltransferase family protein -
BKK80_RS01600 386771..387700 - 930 WP_071068492.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-386)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-67)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49089.28 Da        Isoelectric Point: 8.7017

>T68104 WP_071068490.1 NZ_CP017754:381877-383217 [Cupriavidus malaysiensis]
MGRRSRTRSLGLWMNGVYVGNWQFQPQHGDVLQYAEAWLSAPEGRPLSLSLPFTPGNAAHRGDAVRAYFENLLPDSREIR
DRIARRFRTETTDAFDLLAQVGRDCAGALQLLPDGMAPTGVATIDGEPLNEAQMARALRGAVMQQPPAGADDGEFRISIA
GAQEKTAFLWADGQWLRPRGSTPTSHIFKLPMGLVGNMQLDLGESVENEWLCAQILAAYGMPVAACRPLMFENQKVLCVE
RFDRMWSKGSKPWLIRLPQEDMCQATATPPYRKYEADGGPGIDRIMRLLDGSMHREADRLRFFQAQVLFWMLCAPDGHAK
NFSLALRPGGAYQLTPLYDVMSAYPLLGEGPGKLSPHKVRLAMAVRSSNAHWRVRDIRRRHWLELGRRHAIVTPEGGDAE
SVVNGLAASTPAVVTRVRSLLPAGFPSALADTILGGLQAAADKLAA

Download         Length: 1341 bp

>T68104 NZ_CP017754:381877-383217 [Cupriavidus malaysiensis]
ATGGGGCGCCGCTCTCGCACGCGCAGCCTCGGACTCTGGATGAACGGCGTCTATGTCGGCAACTGGCAGTTCCAGCCGCA
ACACGGGGACGTACTGCAATATGCGGAGGCCTGGCTTTCGGCGCCCGAAGGGCGTCCGCTGTCCTTGTCGCTGCCGTTCA
CGCCGGGCAACGCCGCGCATCGGGGTGACGCCGTGCGCGCCTACTTCGAAAACCTGCTGCCCGACAGTCGGGAGATACGC
GATCGCATTGCACGGCGTTTCCGCACGGAAACGACCGATGCCTTCGATCTGTTGGCACAAGTCGGGCGCGACTGTGCGGG
CGCACTGCAATTGCTGCCGGACGGCATGGCGCCGACAGGCGTCGCCACGATCGATGGGGAACCACTGAACGAAGCGCAGA
TGGCGAGGGCATTGCGCGGAGCGGTCATGCAGCAGCCGCCAGCCGGGGCCGATGATGGTGAGTTCCGCATATCGATCGCC
GGCGCCCAGGAGAAGACTGCTTTCCTGTGGGCGGACGGTCAATGGTTGCGCCCCAGAGGCTCCACGCCCACCAGTCATAT
CTTCAAGCTCCCCATGGGACTGGTCGGCAATATGCAACTGGACCTGGGCGAATCGGTCGAGAATGAATGGCTGTGCGCAC
AGATCCTCGCGGCCTATGGCATGCCCGTGGCCGCTTGCCGGCCGCTCATGTTCGAGAACCAGAAGGTGCTCTGTGTCGAA
CGCTTCGATCGCATGTGGTCGAAGGGAAGCAAGCCCTGGCTCATCCGCCTGCCTCAGGAGGACATGTGCCAGGCCACCGC
CACGCCGCCATATCGGAAGTACGAAGCCGATGGTGGCCCGGGGATCGACCGCATCATGCGTCTGCTCGATGGCTCGATGC
ATCGTGAGGCGGATCGCCTGCGCTTTTTCCAGGCACAGGTTCTGTTCTGGATGCTGTGCGCCCCCGACGGACATGCCAAG
AATTTCAGCTTGGCGTTGCGTCCTGGTGGCGCCTACCAGCTGACACCCCTATACGATGTGATGTCGGCCTATCCACTGCT
TGGCGAAGGACCAGGGAAACTCTCGCCGCACAAGGTCCGCCTGGCGATGGCGGTCCGTTCCAGCAACGCACATTGGCGAG
TACGGGACATCCGGCGGCGGCACTGGCTGGAACTGGGGCGCCGCCACGCCATCGTCACGCCGGAGGGCGGCGACGCGGAG
TCCGTGGTCAACGGTCTCGCAGCAAGCACGCCTGCGGTAGTCACCCGCGTGCGCAGCCTGTTGCCAGCGGGGTTCCCTTC
GGCACTGGCCGACACCATCCTTGGTGGATTGCAGGCGGCGGCGGACAAGCTTGCGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9535.01 Da        Isoelectric Point: 11.0917

>AT68104 WP_071015926.1 NZ_CP017754:381605-381871 [Cupriavidus malaysiensis]
MREFTVRTPEQLPAMLRGFRKQAGLTQAELAARLGVRQQTLSGLERNAESVSAGRLLTLLSVLGVELVLRQADAAAQAAP
PPTDLPQW

Download         Length: 267 bp

>AT68104 NZ_CP017754:381605-381871 [Cupriavidus malaysiensis]
ATGCGCGAATTCACGGTCCGCACGCCCGAGCAACTCCCAGCCATGCTCCGAGGCTTCCGCAAGCAAGCCGGCCTGACCCA
GGCCGAACTGGCTGCCCGTCTGGGCGTACGCCAGCAGACATTGTCGGGGCTGGAGCGCAACGCGGAAAGCGTCAGCGCCG
GGCGCCTGTTGACGCTGCTGTCGGTATTGGGTGTCGAACTCGTGCTTCGGCAAGCGGACGCTGCCGCGCAGGCCGCGCCC
CCGCCAACCGATCTTCCTCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9H2X1

References