Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 501786..503520 Replicon chromosome
Accession NZ_CP017752
Organism Cupriavidus sp. USMAHM13 isolate pure

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BKK81_RS20630 Protein ID WP_071021921.1
Coordinates 502654..503520 (-) Length 289 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BKK81_RS20625 Protein ID WP_071017283.1
Coordinates 501786..502616 (-) Length 277 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK81_RS20605 496908..498383 - 1476 WP_071017276.1 aldehyde dehydrogenase -
BKK81_RS20610 498429..499229 - 801 WP_071017278.1 aspartate dehydrogenase -
BKK81_RS20615 499246..500973 - 1728 WP_071017280.1 thiamine pyrophosphate-binding protein -
BKK81_RS20620 500966..501769 - 804 WP_071017281.1 SDR family oxidoreductase -
BKK81_RS20625 501786..502616 - 831 WP_071017283.1 IclR family transcriptional regulator Antitoxin
BKK81_RS20630 502654..503520 - 867 WP_071021921.1 alpha/beta hydrolase Toxin
BKK81_RS20635 503591..504130 - 540 WP_071017285.1 cupin domain-containing protein -
BKK81_RS20640 504149..504919 - 771 WP_071017287.1 SDR family oxidoreductase -
BKK81_RS20645 504912..505967 - 1056 WP_071021924.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BKK81_RS20650 506018..506323 - 306 WP_071017289.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(34-270)

Antitoxin

Transcription regulator IclR, C-terminal

(138-258)


Sequences

Toxin        


Download         Length: 289 a.a.        Molecular weight: 29520.00 Da        Isoelectric Point: 8.8201

>T68101 WP_071021921.1 NZ_CP017752:c503520-502654 [Cupriavidus sp. USMAHM13]
MLAELDAGFAERTAVLADGARVAYRSGGRQGPLVVLLHGISSGAASWLPCASLLAAQARVLAWDAPGYGASAALAQAAPR
ASDYAARLAGLLEALALHPDVIVGHSLGALMAAAFVAQARPALLPSRLLLLSPAQGYGAPGQQEKAQQVSAQRLQALAQL
GVGGLAERGPQRLLSAAADAGARDWVRWNMRRLNVDGYRQAVAMLCGDAIEPYLQRRAAGVDVRVACGGADVVTTPAASE
ALAQRLGLPFGLVPDAGHVCYIEQPQALARMLRGLLPAAAAPGAAVSH

Download         Length: 867 bp

>T68101 NZ_CP017752:c503520-502654 [Cupriavidus sp. USMAHM13]
CTGCTCGCCGAACTGGACGCGGGCTTCGCCGAGCGCACGGCCGTGCTGGCCGACGGCGCCCGCGTGGCCTACCGCAGCGG
CGGCAGGCAGGGCCCGCTGGTGGTGCTGCTGCACGGCATCAGCTCCGGCGCGGCCTCCTGGCTGCCGTGCGCCAGCCTGC
TGGCGGCGCAGGCGCGCGTGCTGGCATGGGACGCGCCCGGCTACGGCGCTTCCGCCGCGCTGGCGCAAGCGGCGCCGCGC
GCGTCGGACTATGCGGCGCGGCTGGCGGGTTTGCTGGAGGCGCTGGCGCTGCATCCCGACGTCATCGTCGGCCACTCGCT
GGGCGCGCTGATGGCCGCGGCCTTCGTCGCGCAGGCGCGTCCCGCGCTGCTGCCGTCGCGGCTGCTGCTGCTCAGCCCGG
CGCAGGGCTACGGTGCGCCCGGCCAGCAGGAAAAGGCGCAACAGGTGTCGGCGCAGCGGCTGCAGGCGCTGGCGCAGCTC
GGCGTGGGGGGCCTGGCCGAGCGCGGTCCGCAGCGCCTGCTGAGCGCGGCCGCCGATGCCGGCGCGCGCGACTGGGTGCG
CTGGAACATGCGGCGCCTGAACGTGGACGGTTACCGCCAGGCGGTGGCCATGCTGTGCGGCGATGCCATCGAGCCCTACC
TGCAGCGGCGAGCCGCCGGGGTGGACGTGCGGGTGGCCTGCGGCGGCGCGGACGTGGTCACCACGCCGGCGGCGAGCGAG
GCGCTGGCACAGCGCCTGGGCCTGCCTTTCGGGCTGGTGCCCGATGCCGGTCATGTGTGTTATATCGAGCAGCCACAGGC
ACTGGCGCGCATGCTGCGCGGCCTGCTGCCCGCCGCGGCCGCTCCCGGCGCCGCCGTGTCACACTGA

Antitoxin


Download         Length: 277 a.a.        Molecular weight: 30978.64 Da        Isoelectric Point: 6.2906

>AT68101 WP_071017283.1 NZ_CP017752:c502616-501786 [Cupriavidus sp. USMAHM13]
MSKATLPEVLQEKYIVPGLERGLRLLCEFSRKDSTLSAAELARRLQVPRSTVFRLLTTLEMMGFVERTDGGREFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIRYPCNLVVRDGRSIVYVAKSVAPTPFASSVNVGTRLPAHATVLGRVLLEDLS
LAELRELYPESQLEVFSESTPRTVEQLFEMVQHDRQRGYVLQEGFFEASISTIAAPVRDRSGKVAAAMGATIPSSRIDPE
QLGPMVEQVRHAADELSRLLDYRPAAENKVVNLYRE

Download         Length: 831 bp

>AT68101 NZ_CP017752:c502616-501786 [Cupriavidus sp. USMAHM13]
ATGAGCAAAGCCACCCTGCCCGAAGTCCTCCAGGAAAAGTACATCGTGCCGGGCCTGGAGCGCGGACTGCGGCTGCTGTG
CGAATTCAGCCGCAAGGACAGCACGCTGTCGGCGGCCGAACTGGCGCGCCGGCTGCAGGTGCCCCGCTCGACGGTGTTCC
GCCTGCTGACCACGCTGGAGATGATGGGCTTCGTCGAGCGTACCGACGGCGGGCGCGAGTTCCGCCTCGGCATGGCCGTG
CTGCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAACTGACCGAGCTGGGCCGGCCGCTGCTCGACCGCCTGCGCGACGA
CATCCGCTACCCGTGCAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTCGCCAAGTCGGTGGCGCCGACGCCGT
TCGCCAGCTCCGTCAACGTGGGCACGCGCCTGCCGGCGCACGCCACCGTGCTCGGCCGCGTGCTGCTGGAAGACCTGTCG
CTGGCCGAACTGCGCGAGCTCTATCCGGAGTCGCAGCTCGAGGTGTTCTCGGAGAGCACTCCGCGCACCGTCGAGCAACT
GTTCGAGATGGTGCAGCACGACCGCCAGCGCGGCTACGTGCTGCAGGAGGGCTTCTTCGAAGCGAGCATCTCCACCATCG
CGGCGCCGGTGCGCGATCGCAGCGGCAAGGTGGCGGCGGCGATGGGCGCGACGATCCCGTCCTCGCGCATCGATCCGGAG
CAGCTCGGCCCGATGGTGGAACAGGTCCGTCATGCGGCGGACGAGCTCTCGCGCCTGCTGGACTACCGTCCGGCGGCGGA
GAACAAGGTAGTCAACTTATACCGAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References