Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-MazE
Location 275275..275870 Replicon chromosome
Accession NZ_CP017752
Organism Cupriavidus sp. USMAHM13 isolate pure

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag BKK81_RS19645 Protein ID WP_071016973.1
Coordinates 275275..275625 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag BKK81_RS34465 Protein ID WP_083384280.1
Coordinates 275619..275870 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK81_RS35500 270689..270847 + 159 WP_156811396.1 hypothetical protein -
BKK81_RS19620 270930..271703 + 774 WP_071016966.1 hypothetical protein -
BKK81_RS35505 271714..272553 + 840 WP_156811397.1 hypothetical protein -
BKK81_RS35510 272683..273147 + 465 WP_156811398.1 hypothetical protein -
BKK81_RS19630 273272..273688 + 417 WP_071016970.1 NUDIX domain-containing protein -
BKK81_RS19635 273792..274619 + 828 WP_071016971.1 AraC family transcriptional regulator -
BKK81_RS19640 274700..275113 + 414 WP_083384278.1 cupin domain-containing protein -
BKK81_RS34460 275187..275309 - 123 WP_083384279.1 DUF1484 family protein -
BKK81_RS19645 275275..275625 - 351 WP_071016973.1 type II toxin-antitoxin system ChpB family toxin Toxin
BKK81_RS34465 275619..275870 - 252 WP_083384280.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKK81_RS19650 276414..276776 + 363 WP_071039390.1 helix-turn-helix transcriptional regulator -
BKK81_RS19655 276773..278011 + 1239 WP_071016974.1 type II toxin-antitoxin system HipA family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 271957..299718 27761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12305.13 Da        Isoelectric Point: 5.1484

>T68100 WP_071016973.1 NZ_CP017752:c275625-275275 [Cupriavidus sp. USMAHM13]
MVRRAKFDRGDIVRVSLNPTEGREQQGDFRPALVLSPAAFNALGVALVAPITQGGDFARFAGFAVPLSGAGTETQGVALV
NMVRTLDLEACGARKIERAPAEVVEDALARLQTILE

Download         Length: 351 bp

>T68100 NZ_CP017752:c275625-275275 [Cupriavidus sp. USMAHM13]
ATGGTGAGGCGCGCGAAGTTCGACCGGGGCGACATTGTGCGGGTGAGCCTGAACCCAACGGAGGGGCGTGAGCAGCAAGG
GGATTTCCGTCCCGCGCTCGTGCTGTCACCGGCAGCATTCAACGCTCTGGGTGTTGCCCTGGTGGCACCGATTACGCAGG
GCGGCGATTTCGCTCGATTCGCCGGATTTGCCGTACCGTTGTCCGGGGCGGGCACGGAGACCCAAGGCGTCGCGCTGGTG
AACATGGTGCGCACTCTGGATCTTGAAGCTTGCGGTGCGAGGAAGATTGAACGGGCACCTGCCGAGGTCGTGGAAGATGC
GCTCGCCCGTCTTCAAACCATCCTGGAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9127.51 Da        Isoelectric Point: 5.8038

>AT68100 WP_083384280.1 NZ_CP017752:c275870-275619 [Cupriavidus sp. USMAHM13]
MELSIQKWGNSAAVRLPTTLLEQLKVALGDKLSVEVRPDGVMLKPARHKYSLDELLAQCDSKAPTPDGLDDWSGAKPVGR
EVW

Download         Length: 252 bp

>AT68100 NZ_CP017752:c275870-275619 [Cupriavidus sp. USMAHM13]
ATGGAACTGTCGATTCAGAAATGGGGTAACAGCGCGGCCGTGCGCCTGCCCACGACCTTGCTTGAACAACTCAAGGTGGC
GTTGGGCGACAAACTGTCCGTGGAGGTGCGTCCGGATGGTGTCATGCTTAAACCAGCCAGGCACAAGTATTCACTCGATG
AACTGCTTGCGCAGTGCGACTCCAAGGCGCCGACGCCTGACGGGCTGGATGATTGGAGCGGGGCTAAGCCGGTTGGGCGC
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References