Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 140819..141488 Replicon chromosome
Accession NZ_CP017752
Organism Cupriavidus sp. USMAHM13 isolate pure

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BKK81_RS19095 Protein ID WP_071016816.1
Coordinates 141051..141488 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BKK81_RS19090 Protein ID WP_071016815.1
Coordinates 140819..141064 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK81_RS19065 135928..136851 + 924 WP_071016807.1 LysR family transcriptional regulator -
BKK81_RS19070 137160..137672 + 513 WP_071016808.1 hypothetical protein -
BKK81_RS19075 137764..138726 + 963 WP_071016810.1 sterol desaturase family protein -
BKK81_RS19080 138833..139930 + 1098 WP_156811524.1 histidine kinase -
BKK81_RS19085 139938..140747 + 810 WP_071016813.1 LytTR family DNA-binding domain-containing protein -
BKK81_RS19090 140819..141064 + 246 WP_071016815.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKK81_RS19095 141051..141488 + 438 WP_071016816.1 PIN domain-containing protein Toxin
BKK81_RS19100 141600..144716 - 3117 WP_071016818.1 efflux RND transporter permease subunit -
BKK81_RS19105 144730..146007 - 1278 WP_083384255.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(18-125)

Antitoxin

SpoVT-AbrB domain

(5-35)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15675.14 Da        Isoelectric Point: 6.0806

>T68099 WP_071016816.1 NZ_CP017752:141051-141488 [Cupriavidus sp. USMAHM13]
MGGIESSRAAGRGKAEGFLDSNVLLYLLSADAAKADRAEALLRSRPVISVQVLNEVTHVCVRKLGMRWDEVDEFLTLVKS
LCRIAPLTVDMHDLARRLAARYGLAFYDACIVACASLEGCETLYSEAMHHGPAVEGGPVLANPFL

Download         Length: 438 bp

>T68099 NZ_CP017752:141051-141488 [Cupriavidus sp. USMAHM13]
ATGGGCGGGATTGAGTCCTCCCGCGCAGCGGGTCGCGGCAAGGCCGAAGGATTCCTTGACAGCAATGTCCTGCTCTACCT
GCTGTCGGCCGATGCCGCCAAGGCCGACCGCGCCGAAGCGCTGCTGCGCAGCAGGCCGGTCATCAGCGTCCAGGTGCTGA
ACGAAGTCACCCACGTCTGCGTGCGCAAGCTCGGCATGCGCTGGGACGAAGTCGACGAGTTCCTAACGCTGGTCAAGAGC
CTGTGCCGCATCGCGCCGTTGACCGTGGACATGCACGACCTGGCGCGGCGTCTCGCCGCGCGGTACGGCCTGGCGTTCTA
TGACGCCTGCATCGTGGCTTGTGCGTCGCTCGAGGGCTGCGAGACGCTCTACAGCGAAGCCATGCATCACGGCCCCGCCG
TCGAGGGCGGGCCGGTGCTGGCGAACCCTTTCCTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9306.50 Da        Isoelectric Point: 8.9101

>AT68099 WP_071016815.1 NZ_CP017752:140819-141064 [Cupriavidus sp. USMAHM13]
MQVAKWGNSLAVRLPASVVEALELREGDDIEIVVEHSRTFAIRRKPGTDELLQRLRRFRGRLPADFKFSRDDANERGDGR
D

Download         Length: 246 bp

>AT68099 NZ_CP017752:140819-141064 [Cupriavidus sp. USMAHM13]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTCGCCGTGCGCCTGCCGGCAAGCGTGGTGGAAGCGCTGGAATTGCGCGAGGG
CGACGATATCGAGATCGTGGTCGAGCATTCCCGCACCTTCGCCATCCGCAGGAAGCCGGGAACGGATGAACTGCTGCAGC
GCCTGCGCCGATTCCGCGGCCGGCTCCCGGCCGACTTCAAGTTCAGCCGCGACGATGCCAACGAGCGGGGCGATGGGCGG
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References