Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 375396..376036 | Replicon | plasmid unnamed1 |
Accession | NZ_CP017750 | ||
Organism | Cupriavidus sp. USMAA2-4 isolate pure |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A1D9HCW7 |
Locus tag | BKK79_RS37790 | Protein ID | WP_071040774.1 |
Coordinates | 375396..375797 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A1D9HCW3 |
Locus tag | BKK79_RS37795 | Protein ID | WP_071040775.1 |
Coordinates | 375794..376036 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BKK79_RS39865 | 371471..371941 | + | 471 | Protein_355 | cupin domain-containing protein | - |
BKK79_RS37775 | 372381..373589 | + | 1209 | WP_011517431.1 | IS4-like element ISBvi1 family transposase | - |
BKK79_RS37780 | 373859..374083 | - | 225 | WP_071040772.1 | hypothetical protein | - |
BKK79_RS37785 | 374064..374627 | - | 564 | WP_071040773.1 | hypothetical protein | - |
BKK79_RS37790 | 375396..375797 | - | 402 | WP_071040774.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
BKK79_RS37795 | 375794..376036 | - | 243 | WP_071040775.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
BKK79_RS37800 | 376571..377656 | + | 1086 | WP_071040776.1 | HNH endonuclease | - |
BKK79_RS37805 | 377725..379899 | + | 2175 | WP_071040777.1 | tyrosine-type recombinase/integrase | - |
BKK79_RS37810 | 380191..380853 | - | 663 | WP_071040867.1 | RES family NAD+ phosphorylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..544877 | 544877 | |
- | flank | IS/Tn | - | - | 372390..373589 | 1199 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14674.72 Da Isoelectric Point: 6.3759
>T68095 WP_071040774.1 NZ_CP017750:c375797-375396 [Cupriavidus sp. USMAA2-4]
MKYLLDANAVIALLKGEPTFLEHLRAHLPTDFGLPAIVAHELYYGAYKSQRAAANLGRIEALQFEVIPFDAEDAQHASEI
RAQLAGAGTPIGPYDVLIAGQARARNLVLVTHNVREFARVPQLRVEDWHGEAH
MKYLLDANAVIALLKGEPTFLEHLRAHLPTDFGLPAIVAHELYYGAYKSQRAAANLGRIEALQFEVIPFDAEDAQHASEI
RAQLAGAGTPIGPYDVLIAGQARARNLVLVTHNVREFARVPQLRVEDWHGEAH
Download Length: 402 bp
>T68095 NZ_CP017750:c375797-375396 [Cupriavidus sp. USMAA2-4]
ATGAAATACCTGCTCGACGCCAACGCGGTGATCGCGCTGCTCAAGGGCGAGCCCACCTTTCTCGAGCACCTGCGTGCACA
CTTGCCGACCGATTTTGGCTTACCGGCGATCGTCGCCCACGAGCTTTACTATGGCGCCTACAAGAGCCAGCGCGCGGCCG
CCAACCTGGGCCGCATCGAGGCGCTGCAGTTTGAAGTGATACCGTTTGATGCGGAGGACGCCCAGCACGCCAGTGAGATT
CGCGCACAGTTGGCAGGCGCTGGCACGCCGATCGGCCCCTACGACGTGCTGATTGCTGGGCAGGCGAGGGCGCGCAACTT
GGTACTGGTAACCCACAACGTGCGCGAGTTTGCCCGCGTGCCCCAACTGCGCGTCGAAGACTGGCATGGCGAGGCTCACT
GA
ATGAAATACCTGCTCGACGCCAACGCGGTGATCGCGCTGCTCAAGGGCGAGCCCACCTTTCTCGAGCACCTGCGTGCACA
CTTGCCGACCGATTTTGGCTTACCGGCGATCGTCGCCCACGAGCTTTACTATGGCGCCTACAAGAGCCAGCGCGCGGCCG
CCAACCTGGGCCGCATCGAGGCGCTGCAGTTTGAAGTGATACCGTTTGATGCGGAGGACGCCCAGCACGCCAGTGAGATT
CGCGCACAGTTGGCAGGCGCTGGCACGCCGATCGGCCCCTACGACGTGCTGATTGCTGGGCAGGCGAGGGCGCGCAACTT
GGTACTGGTAACCCACAACGTGCGCGAGTTTGCCCGCGTGCCCCAACTGCGCGTCGAAGACTGGCATGGCGAGGCTCACT
GA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8895.07 Da Isoelectric Point: 4.7483
>AT68095 WP_071040775.1 NZ_CP017750:c376036-375794 [Cupriavidus sp. USMAA2-4]
METAKIFRHGGSQAVRLPKDFRFDSTEVRIRRHGAAVILEPVPQDWAWLAPLVGPLDADFEAAALAQPDAQERPGLDVFE
METAKIFRHGGSQAVRLPKDFRFDSTEVRIRRHGAAVILEPVPQDWAWLAPLVGPLDADFEAAALAQPDAQERPGLDVFE
Download Length: 243 bp
>AT68095 NZ_CP017750:c376036-375794 [Cupriavidus sp. USMAA2-4]
ATGGAAACGGCCAAGATCTTTCGCCACGGGGGCTCGCAGGCCGTGCGCCTGCCCAAGGACTTCCGTTTTGACAGCACCGA
GGTGCGCATCCGCCGGCACGGCGCCGCCGTCATCCTCGAACCCGTGCCGCAGGACTGGGCGTGGCTCGCGCCGCTGGTCG
GCCCGCTCGATGCCGACTTTGAGGCCGCCGCGCTTGCCCAGCCCGACGCACAGGAGCGCCCCGGCCTGGACGTGTTCGAA
TGA
ATGGAAACGGCCAAGATCTTTCGCCACGGGGGCTCGCAGGCCGTGCGCCTGCCCAAGGACTTCCGTTTTGACAGCACCGA
GGTGCGCATCCGCCGGCACGGCGCCGCCGTCATCCTCGAACCCGTGCCGCAGGACTGGGCGTGGCTCGCGCCGCTGGTCG
GCCCGCTCGATGCCGACTTTGAGGCCGCCGCGCTTGCCCAGCCCGACGCACAGGAGCGCCCCGGCCTGGACGTGTTCGAA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9HCW7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9HCW3 |