Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2443420..2444057 Replicon chromosome
Accession NZ_CP017749
Organism Cupriavidus sp. USMAA2-4 isolate pure

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D9H853
Locus tag BKK79_RS30750 Protein ID WP_071021112.1
Coordinates 2443420..2443821 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1D9H848
Locus tag BKK79_RS30755 Protein ID WP_071021111.1
Coordinates 2443821..2444057 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK79_RS30735 2439558..2440832 - 1275 WP_071039726.1 cytochrome P450 -
BKK79_RS30740 2441350..2442891 + 1542 WP_071021117.1 MCP four helix bundle domain-containing protein -
BKK79_RS30745 2442943..2443311 - 369 WP_071021114.1 cytochrome c family protein -
BKK79_RS30750 2443420..2443821 - 402 WP_071021112.1 type II toxin-antitoxin system VapC family toxin Toxin
BKK79_RS30755 2443821..2444057 - 237 WP_071021111.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKK79_RS30760 2444320..2445288 + 969 Protein_2158 translesion DNA synthesis-associated protein ImuA -
BKK79_RS41275 2445224..2446771 + 1548 WP_071040476.1 DNA polymerase Y family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15117.40 Da        Isoelectric Point: 6.0839

>T68093 WP_071021112.1 NZ_CP017749:c2443821-2443420 [Cupriavidus sp. USMAA2-4]
MPRFMLDTNMCIYLMRDQPEQVARRFAQCYVGDVVMSAITYAELEYGVAVSADPARERLHLASLVEDIPVMPFEAAAARA
YGPVRQATRERRKDHLDKLIAAHALALDLVLVTNNERDFAHYPGLRLENWLQG

Download         Length: 402 bp

>T68093 NZ_CP017749:c2443821-2443420 [Cupriavidus sp. USMAA2-4]
ATGCCGCGCTTCATGCTCGACACCAATATGTGCATCTACCTGATGCGGGACCAGCCCGAGCAGGTGGCGAGACGCTTTGC
GCAATGCTATGTCGGTGACGTGGTGATGTCTGCCATCACCTATGCCGAACTGGAATACGGCGTCGCCGTGTCGGCCGACC
CCGCCCGGGAACGCCTGCACCTCGCCTCGCTGGTCGAGGACATTCCGGTGATGCCCTTCGAGGCGGCCGCGGCGCGGGCC
TACGGCCCCGTCCGGCAGGCGACGCGCGAGCGCAGGAAGGACCATCTGGACAAGCTGATCGCAGCCCATGCGCTGGCACT
GGACCTGGTCCTGGTCACCAACAACGAAAGAGACTTCGCGCACTATCCGGGCCTGCGGCTGGAGAACTGGCTGCAGGGAT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8937.04 Da        Isoelectric Point: 5.1679

>AT68093 WP_071021111.1 NZ_CP017749:c2444057-2443821 [Cupriavidus sp. USMAA2-4]
MHTTRLFKNGNSQAVRIPADLAYDRTDVELEIERIGDEIRIRPARRPLAGVLEKFAKFGPDFMAEGRDEHGQDEREAL

Download         Length: 237 bp

>AT68093 NZ_CP017749:c2444057-2443821 [Cupriavidus sp. USMAA2-4]
ATGCACACCACACGCCTCTTCAAGAACGGCAACTCGCAGGCCGTGCGTATTCCGGCCGACCTGGCCTACGACCGCACCGA
CGTGGAACTGGAGATCGAGCGCATCGGCGACGAGATCCGCATCCGCCCGGCGCGCCGGCCGCTGGCCGGGGTTCTGGAGA
AGTTCGCGAAATTCGGCCCGGACTTCATGGCCGAGGGCCGCGACGAGCACGGCCAGGACGAGCGCGAGGCCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9H853

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9H848

References