Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1818037..1818706 Replicon chromosome
Accession NZ_CP017749
Organism Cupriavidus sp. USMAA2-4 isolate pure

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D9H736
Locus tag BKK79_RS28120 Protein ID WP_071039453.1
Coordinates 1818037..1818474 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D9H6W9
Locus tag BKK79_RS28125 Protein ID WP_071039454.1
Coordinates 1818461..1818706 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK79_RS28110 1813518..1814795 + 1278 WP_083384255.1 efflux RND transporter periplasmic adaptor subunit -
BKK79_RS28115 1814809..1817925 + 3117 WP_071016818.1 efflux RND transporter permease subunit -
BKK79_RS28120 1818037..1818474 - 438 WP_071039453.1 PIN domain-containing protein Toxin
BKK79_RS28125 1818461..1818706 - 246 WP_071039454.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BKK79_RS28130 1818778..1819587 - 810 WP_071039455.1 LytTR family DNA-binding domain-containing protein -
BKK79_RS28135 1819595..1820692 - 1098 WP_157128636.1 histidine kinase -
BKK79_RS28140 1820799..1821761 - 963 WP_071039457.1 sterol desaturase family protein -
BKK79_RS28145 1821852..1822364 - 513 WP_071039458.1 hypothetical protein -
BKK79_RS28150 1822645..1823568 - 924 WP_071039459.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(18-128)

Antitoxin

SpoVT-AbrB domain

(5-35)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15735.19 Da        Isoelectric Point: 5.6128

>T68092 WP_071039453.1 NZ_CP017749:c1818474-1818037 [Cupriavidus sp. USMAA2-4]
MGGIESSRAAGRGKAEGFLDSNVLLYLLSADAAKADRAEALLRSRPVISVQVLNEVTHVCVRKLGMRWDEVDEFLTLVKS
LCRIAPLTVDMHDLARRLAARYGLAFYDACIVACASLEGCETLYSEDMHHGLAVEGGPVLANPFL

Download         Length: 438 bp

>T68092 NZ_CP017749:c1818474-1818037 [Cupriavidus sp. USMAA2-4]
ATGGGCGGGATTGAGTCCTCCCGCGCAGCGGGTCGCGGCAAGGCCGAAGGATTCCTTGACAGCAATGTCCTGCTCTACCT
GCTGTCGGCCGATGCCGCCAAGGCCGACCGCGCCGAAGCGCTGCTGCGCAGCAGGCCGGTCATCAGCGTCCAGGTGCTGA
ACGAAGTCACCCACGTCTGCGTGCGCAAGCTCGGCATGCGCTGGGACGAAGTCGACGAGTTCCTGACGCTGGTCAAGAGC
CTGTGCCGCATCGCGCCGTTGACCGTGGACATGCACGACCTGGCGCGGCGTCTCGCCGCGCGGTACGGCCTGGCGTTCTA
TGACGCCTGCATCGTGGCTTGTGCGTCGCTCGAGGGCTGCGAGACGCTCTACAGCGAAGACATGCATCACGGCCTCGCCG
TCGAGGGCGGGCCGGTGCTGGCGAACCCTTTCCTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9355.53 Da        Isoelectric Point: 6.3711

>AT68092 WP_071039454.1 NZ_CP017749:c1818706-1818461 [Cupriavidus sp. USMAA2-4]
MQVAKWGNSLAVRLPASVVEALELREGDDIEIVVEQSRTFAIRRKPGTDELLQRLRRFRGRLPADFKFSRDDANERDDGR
D

Download         Length: 246 bp

>AT68092 NZ_CP017749:c1818706-1818461 [Cupriavidus sp. USMAA2-4]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTCGCCGTGCGCCTGCCGGCAAGCGTGGTGGAAGCGCTGGAATTGCGCGAGGG
CGACGATATCGAGATCGTGGTCGAGCAGTCCCGCACCTTCGCCATCCGCAGGAAGCCGGGAACGGATGAACTGCTGCAGC
GCCTGCGCCGATTCCGTGGCCGGCTCCCGGCCGACTTCAAGTTCAGCCGCGACGATGCCAACGAGCGGGACGATGGGCGG
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9H736

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9H6W9

References