Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 830859..831388 Replicon chromosome
Accession NZ_CP017749
Organism Cupriavidus sp. USMAA2-4 isolate pure

Toxin (Protein)


Gene name relE Uniprot ID A0A1D9H4T3
Locus tag BKK79_RS23795 Protein ID WP_071018114.1
Coordinates 830859..831128 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1D9H5D1
Locus tag BKK79_RS23800 Protein ID WP_071018112.1
Coordinates 831125..831388 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKK79_RS23775 827308..829002 + 1695 WP_071039015.1 amidohydrolase -
BKK79_RS23780 829176..830090 + 915 WP_071039016.1 phosphorylase -
BKK79_RS23785 830176..830480 + 305 Protein_735 tripartite tricarboxylate transporter substrate binding protein -
BKK79_RS23790 830524..830790 - 267 WP_071018116.1 hypothetical protein -
BKK79_RS23795 830859..831128 - 270 WP_071018114.1 Txe/YoeB family addiction module toxin Toxin
BKK79_RS23800 831125..831388 - 264 WP_071018112.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BKK79_RS23805 831464..832183 - 720 WP_071018110.1 amino acid racemase -
BKK79_RS23810 832472..832951 + 480 WP_071039019.1 YiaA/YiaB family protein -
BKK79_RS23815 833025..833957 - 933 WP_071039021.1 LysR family transcriptional regulator -
BKK79_RS23820 834062..835354 + 1293 WP_071018105.1 MFS transporter -
BKK79_RS23825 835393..836367 - 975 WP_071039023.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10486.81 Da        Isoelectric Point: 8.0151

>T68088 WP_071018114.1 NZ_CP017749:c831128-830859 [Cupriavidus sp. USMAA2-4]
MTRQLVFMPDAWDDYLYWQGQDRKTLKRINQLIQDTTRNPFDGVGKPEPLTGNLSGYWSRRIDNTNRLVYHANDDELTII
ACRLHYGAK

Download         Length: 270 bp

>T68088 NZ_CP017749:c831128-830859 [Cupriavidus sp. USMAA2-4]
ATGACGCGCCAGCTGGTCTTCATGCCCGACGCGTGGGATGACTATCTCTACTGGCAAGGACAGGACAGAAAGACGCTCAA
GCGAATCAATCAGCTCATCCAGGACACCACGCGTAACCCTTTCGATGGAGTCGGCAAGCCTGAGCCCCTGACGGGGAATC
TGTCCGGCTACTGGTCGCGCCGCATCGACAATACCAACCGTCTCGTTTATCACGCCAACGATGACGAGTTGACCATCATT
GCCTGTCGCCTGCACTACGGCGCCAAGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9935.13 Da        Isoelectric Point: 4.8134

>AT68088 WP_071018112.1 NZ_CP017749:c831388-831125 [Cupriavidus sp. USMAA2-4]
MRTVHFSDARNNLKAVIDQAIADHDAILITRRDAPNAVIMSQEQYDSWMETMYLLSSPANAERLLRSIEQHRRGEGVERE
LIDPDAA

Download         Length: 264 bp

>AT68088 NZ_CP017749:c831388-831125 [Cupriavidus sp. USMAA2-4]
ATGCGCACCGTTCATTTCTCCGATGCCCGCAACAACCTGAAGGCCGTGATCGACCAGGCCATCGCCGATCACGATGCCAT
CCTGATCACACGGCGCGATGCGCCCAATGCCGTGATCATGTCGCAGGAACAGTACGACAGCTGGATGGAAACCATGTACC
TGCTCAGTTCGCCGGCCAATGCGGAGCGCTTGCTGCGCTCCATCGAGCAGCATCGCCGGGGCGAGGGGGTGGAGCGTGAG
TTGATCGATCCGGACGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9H4T3

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9H5D1

References