Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2412475..2414087 | Replicon | chromosome |
Accession | NZ_CP017748 | ||
Organism | Cupriavidus sp. USMAA2-4 isolate pure |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A1D9GX78 |
Locus tag | BKK79_RS10635 | Protein ID | WP_071037679.1 |
Coordinates | 2412475..2413815 (-) | Length | 447 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A1D9H2X1 |
Locus tag | BKK79_RS10640 | Protein ID | WP_071015926.1 |
Coordinates | 2413821..2414087 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BKK79_RS10605 | 2407999..2408928 | + | 930 | WP_071037677.1 | alpha/beta hydrolase | - |
BKK79_RS10610 | 2409051..2409659 | + | 609 | WP_198173327.1 | lecithin retinol acyltransferase family protein | - |
BKK79_RS10615 | 2409656..2410177 | + | 522 | WP_084084665.1 | dethiobiotin synthetase | - |
BKK79_RS10620 | 2410298..2410900 | + | 603 | WP_071037678.1 | RNA polymerase sigma factor | - |
BKK79_RS10625 | 2410890..2411756 | + | 867 | WP_157128418.1 | anti-sigma factor | - |
BKK79_RS10630 | 2411916..2412152 | + | 237 | WP_071010575.1 | hypothetical protein | - |
BKK79_RS40290 | 2412145..2412384 | + | 240 | WP_157128419.1 | hypothetical protein | - |
BKK79_RS10635 | 2412475..2413815 | - | 1341 | WP_071037679.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
BKK79_RS10640 | 2413821..2414087 | - | 267 | WP_071015926.1 | helix-turn-helix domain-containing protein | Antitoxin |
BKK79_RS10645 | 2414277..2414552 | - | 276 | WP_071010573.1 | muconolactone Delta-isomerase | - |
BKK79_RS10650 | 2414673..2415011 | - | 339 | WP_071010572.1 | 4-methylmuconolactone methylisomerase | - |
BKK79_RS10655 | 2415105..2416391 | - | 1287 | WP_071037680.1 | MFS transporter | - |
BKK79_RS10660 | 2416574..2417236 | - | 663 | WP_071010570.1 | 3-oxoacid CoA-transferase subunit B | - |
BKK79_RS10665 | 2417242..2417985 | - | 744 | WP_071010569.1 | 3-oxoacid CoA-transferase subunit A | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 447 a.a. Molecular weight: 49163.36 Da Isoelectric Point: 8.4868
>T68087 WP_071037679.1 NZ_CP017748:c2413815-2412475 [Cupriavidus sp. USMAA2-4]
MGRRSRTRSLGLWMNGVYVGNWQFQPQHGDVLQYAEAWLSAPEGRPLSLSLPFTPGNAAHRGDAVRAYFENLLPDSREIR
DRIARRFRTETTDAFDLLAQVGRDCVGALQLLPDGMAPTGVATIDGEPLNEAQMARALRGAVMQQPPAEADDGEFRISIA
GAQEKTAFLWADGQWLRPRGSTPTSHIFKLPMGLVGNMQLDLGESVENEWLCAQILAAYGMPVAACRPLMFENQKVLCVE
RFDRMWSKGSKPWLIRLPQEDMCQATATPPYRKHEADGGPGIDRIMRLLDGSMHREADRLRFFQAQVLFWMLCAPDGHAK
NFSLALRPGGAYQLTPLYDVMSAYPLLGEGPGKLSPHKVRLAMAVRSSNAHWRVRDIRRRHWLELGRRHAIVTPEGGDAE
SVVNGLAASTPAVVTRVRSLLPAGFPSALADTILGGLQAAADKLAA
MGRRSRTRSLGLWMNGVYVGNWQFQPQHGDVLQYAEAWLSAPEGRPLSLSLPFTPGNAAHRGDAVRAYFENLLPDSREIR
DRIARRFRTETTDAFDLLAQVGRDCVGALQLLPDGMAPTGVATIDGEPLNEAQMARALRGAVMQQPPAEADDGEFRISIA
GAQEKTAFLWADGQWLRPRGSTPTSHIFKLPMGLVGNMQLDLGESVENEWLCAQILAAYGMPVAACRPLMFENQKVLCVE
RFDRMWSKGSKPWLIRLPQEDMCQATATPPYRKHEADGGPGIDRIMRLLDGSMHREADRLRFFQAQVLFWMLCAPDGHAK
NFSLALRPGGAYQLTPLYDVMSAYPLLGEGPGKLSPHKVRLAMAVRSSNAHWRVRDIRRRHWLELGRRHAIVTPEGGDAE
SVVNGLAASTPAVVTRVRSLLPAGFPSALADTILGGLQAAADKLAA
Download Length: 1341 bp
>T68087 NZ_CP017748:c2413815-2412475 [Cupriavidus sp. USMAA2-4]
ATGGGGCGCCGCTCTCGCACGCGCAGCCTCGGACTCTGGATGAACGGCGTCTATGTCGGCAACTGGCAGTTCCAGCCGCA
ACACGGGGACGTACTGCAATATGCGGAGGCCTGGCTTTCGGCGCCCGAAGGGCGTCCGCTGTCCTTGTCGCTGCCGTTCA
CGCCGGGCAACGCCGCGCATCGGGGTGACGCCGTGCGCGCCTACTTCGAAAACCTGCTGCCCGACAGTCGGGAGATACGC
GATCGCATTGCACGGCGTTTCCGCACGGAAACGACCGATGCCTTCGATCTGTTGGCACAAGTCGGGCGCGACTGTGTGGG
CGCACTGCAATTGCTGCCGGACGGCATGGCGCCGACAGGCGTCGCCACGATCGATGGGGAACCACTGAACGAAGCGCAGA
TGGCGAGGGCATTGCGCGGAGCGGTCATGCAGCAGCCGCCAGCCGAGGCCGATGATGGTGAGTTCCGCATATCGATCGCC
GGCGCCCAGGAGAAGACTGCTTTCCTGTGGGCGGACGGTCAATGGTTGCGCCCCAGAGGCTCCACGCCCACCAGTCATAT
CTTCAAGCTCCCCATGGGACTGGTCGGCAATATGCAACTGGACCTGGGCGAATCGGTCGAGAATGAATGGCTGTGCGCAC
AGATCCTCGCGGCCTATGGCATGCCCGTGGCCGCTTGCCGGCCGCTCATGTTCGAGAACCAGAAGGTGCTCTGTGTCGAA
CGCTTCGATCGCATGTGGTCGAAGGGAAGCAAGCCCTGGCTCATCCGCCTGCCTCAGGAGGACATGTGCCAGGCCACCGC
CACGCCGCCATATCGGAAGCACGAAGCCGATGGTGGCCCGGGGATCGACCGCATCATGCGTCTGCTCGATGGCTCGATGC
ATCGTGAGGCGGATCGCCTGCGCTTTTTCCAGGCACAGGTTCTGTTCTGGATGCTGTGCGCCCCCGACGGACATGCCAAG
AATTTCAGCTTGGCGTTGCGTCCTGGTGGCGCCTACCAGCTGACACCCCTATACGATGTGATGTCGGCCTATCCACTGCT
TGGCGAAGGACCAGGGAAACTCTCGCCGCACAAGGTCCGCCTGGCGATGGCGGTCCGTTCCAGCAACGCACATTGGCGAG
TACGGGACATCCGGCGGCGGCACTGGCTGGAACTGGGGCGCCGCCACGCCATCGTCACGCCGGAGGGCGGCGACGCGGAG
TCCGTGGTCAACGGTCTCGCAGCAAGCACGCCTGCGGTAGTCACCCGCGTGCGCAGCCTGTTGCCAGCGGGGTTCCCTTC
GGCACTGGCCGACACCATCCTTGGTGGATTGCAGGCGGCGGCGGACAAGCTTGCGGCCTGA
ATGGGGCGCCGCTCTCGCACGCGCAGCCTCGGACTCTGGATGAACGGCGTCTATGTCGGCAACTGGCAGTTCCAGCCGCA
ACACGGGGACGTACTGCAATATGCGGAGGCCTGGCTTTCGGCGCCCGAAGGGCGTCCGCTGTCCTTGTCGCTGCCGTTCA
CGCCGGGCAACGCCGCGCATCGGGGTGACGCCGTGCGCGCCTACTTCGAAAACCTGCTGCCCGACAGTCGGGAGATACGC
GATCGCATTGCACGGCGTTTCCGCACGGAAACGACCGATGCCTTCGATCTGTTGGCACAAGTCGGGCGCGACTGTGTGGG
CGCACTGCAATTGCTGCCGGACGGCATGGCGCCGACAGGCGTCGCCACGATCGATGGGGAACCACTGAACGAAGCGCAGA
TGGCGAGGGCATTGCGCGGAGCGGTCATGCAGCAGCCGCCAGCCGAGGCCGATGATGGTGAGTTCCGCATATCGATCGCC
GGCGCCCAGGAGAAGACTGCTTTCCTGTGGGCGGACGGTCAATGGTTGCGCCCCAGAGGCTCCACGCCCACCAGTCATAT
CTTCAAGCTCCCCATGGGACTGGTCGGCAATATGCAACTGGACCTGGGCGAATCGGTCGAGAATGAATGGCTGTGCGCAC
AGATCCTCGCGGCCTATGGCATGCCCGTGGCCGCTTGCCGGCCGCTCATGTTCGAGAACCAGAAGGTGCTCTGTGTCGAA
CGCTTCGATCGCATGTGGTCGAAGGGAAGCAAGCCCTGGCTCATCCGCCTGCCTCAGGAGGACATGTGCCAGGCCACCGC
CACGCCGCCATATCGGAAGCACGAAGCCGATGGTGGCCCGGGGATCGACCGCATCATGCGTCTGCTCGATGGCTCGATGC
ATCGTGAGGCGGATCGCCTGCGCTTTTTCCAGGCACAGGTTCTGTTCTGGATGCTGTGCGCCCCCGACGGACATGCCAAG
AATTTCAGCTTGGCGTTGCGTCCTGGTGGCGCCTACCAGCTGACACCCCTATACGATGTGATGTCGGCCTATCCACTGCT
TGGCGAAGGACCAGGGAAACTCTCGCCGCACAAGGTCCGCCTGGCGATGGCGGTCCGTTCCAGCAACGCACATTGGCGAG
TACGGGACATCCGGCGGCGGCACTGGCTGGAACTGGGGCGCCGCCACGCCATCGTCACGCCGGAGGGCGGCGACGCGGAG
TCCGTGGTCAACGGTCTCGCAGCAAGCACGCCTGCGGTAGTCACCCGCGTGCGCAGCCTGTTGCCAGCGGGGTTCCCTTC
GGCACTGGCCGACACCATCCTTGGTGGATTGCAGGCGGCGGCGGACAAGCTTGCGGCCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9535.01 Da Isoelectric Point: 11.0917
>AT68087 WP_071015926.1 NZ_CP017748:c2414087-2413821 [Cupriavidus sp. USMAA2-4]
MREFTVRTPEQLPAMLRGFRKQAGLTQAELAARLGVRQQTLSGLERNAESVSAGRLLTLLSVLGVELVLRQADAAAQAAP
PPTDLPQW
MREFTVRTPEQLPAMLRGFRKQAGLTQAELAARLGVRQQTLSGLERNAESVSAGRLLTLLSVLGVELVLRQADAAAQAAP
PPTDLPQW
Download Length: 267 bp
>AT68087 NZ_CP017748:c2414087-2413821 [Cupriavidus sp. USMAA2-4]
ATGCGCGAATTCACGGTCCGCACGCCCGAGCAACTCCCAGCCATGCTCCGAGGCTTCCGCAAGCAAGCCGGCCTGACCCA
GGCCGAACTGGCTGCCCGTCTGGGCGTACGCCAGCAGACATTGTCGGGGCTGGAGCGCAACGCGGAAAGCGTCAGCGCCG
GGCGCCTGTTGACGCTGCTGTCGGTATTGGGTGTCGAACTCGTGCTTCGGCAAGCGGACGCTGCCGCGCAGGCCGCGCCC
CCGCCAACCGATCTTCCTCAGTGGTGA
ATGCGCGAATTCACGGTCCGCACGCCCGAGCAACTCCCAGCCATGCTCCGAGGCTTCCGCAAGCAAGCCGGCCTGACCCA
GGCCGAACTGGCTGCCCGTCTGGGCGTACGCCAGCAGACATTGTCGGGGCTGGAGCGCAACGCGGAAAGCGTCAGCGCCG
GGCGCCTGTTGACGCTGCTGTCGGTATTGGGTGTCGAACTCGTGCTTCGGCAAGCGGACGCTGCCGCGCAGGCCGCGCCC
CCGCCAACCGATCTTCCTCAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9GX78 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1D9H2X1 |