Detailed information of TA system TA068078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 102501..103026
• Replicon: plasmid pCFSAN017963_01
• Accession: NZ_CP017721
• Organism: Salmonella enterica subsp. enterica serovar Minnesota strain CFSAN017963

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: GX95_RS24580
• Protein ID: WP_088137220.1
• Coordinates: 102721..103026 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: GX95_RS24575
• Protein ID: WP_088137219.1
• Coordinates: 102501..102719 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GX95_RS24545	97586..98422	-	837	WP_088137214.1	outer membrane protein OmpK	-
GX95_RS24550	98518..99672	-	1155	WP_088137215.1	MFS transporter TsgA	-
GX95_RS24555	99711..100418	-	708	WP_088137216.1	purine-nucleoside phosphorylase	-
GX95_RS24565	101184..101798	-	615	WP_088137217.1	DNA-binding protein	-
GX95_RS24575	102501..102719	+	219	WP_088137219.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
GX95_RS24580	102721..103026	+	306	WP_088137220.1	type II toxin-antitoxin system toxin CcdB	Toxin
GX95_RS24585	103028..103309	+	282	WP_088137221.1	cytoplasmic protein	-
GX95_RS24590	103406..103840	+	435	WP_088137222.1	hypothetical protein	-
GX95_RS24595	103837..104619	+	783	WP_088137223.1	site-specific integrase	-
GX95_RS24600	105123..105818	+	696	WP_088137224.1	CPBP family intramembrane metalloprotease	-
GX95_RS26065	106433..106585	-	153	WP_001838496.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..280421	280421

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T68078 WP_088137220.1 NZ_CP017721:102721-103026 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T68078 NZ_CP017721:102721-103026 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT68078 WP_088137219.1 NZ_CP017721:102501-102719 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT68078 NZ_CP017721:102501-102719 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA