Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3287106..3287512 Replicon chromosome
Accession NZ_CP017708
Organism Moorea producens JHB

Toxin (Protein)


Gene name hicA Uniprot ID A0A1D9FZA1
Locus tag BJP36_RS12475 Protein ID WP_071104008.1
Coordinates 3287106..3287300 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F4Y188
Locus tag BJP36_RS12480 Protein ID WP_008189734.1
Coordinates 3287297..3287512 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP36_RS36480 3282833..3283040 - 208 Protein_2848 CopG family transcriptional regulator -
BJP36_RS12440 3283122..3283397 - 276 WP_202970786.1 DUF433 domain-containing protein -
BJP36_RS12445 3283690..3283884 + 195 Protein_2850 type II toxin-antitoxin system RelE/ParE family toxin -
BJP36_RS12450 3283881..3284183 + 303 WP_071104003.1 helix-turn-helix domain-containing protein -
BJP36_RS12455 3284362..3285384 - 1023 WP_071104004.1 hypothetical protein -
BJP36_RS12460 3285643..3285801 - 159 WP_071104005.1 type II toxin-antitoxin system HicB family antitoxin -
BJP36_RS12465 3286037..3286219 - 183 WP_071104006.1 type II toxin-antitoxin system HicA family toxin -
BJP36_RS12470 3286216..3286407 - 192 WP_071104007.1 hypothetical protein -
BJP36_RS12475 3287106..3287300 + 195 WP_071104008.1 type II toxin-antitoxin system HicA family toxin Toxin
BJP36_RS12480 3287297..3287512 + 216 WP_008189734.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BJP36_RS12485 3287617..3288477 - 861 WP_071104009.1 hypothetical protein -
BJP36_RS12490 3288539..3288760 - 222 WP_071104010.1 hypothetical protein -
BJP36_RS12495 3288889..3289836 - 948 WP_008189727.1 hypothetical protein -
BJP36_RS12500 3289982..3291640 - 1659 WP_071104011.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7257.63 Da        Isoelectric Point: 11.0108

>T68072 WP_071104008.1 NZ_CP017708:3287106-3287300 [Moorena producens JHB]
MKVKEVLKRLKKDGWYQVRMRGSHRILAHPQKPGIVVVPGKLSDEIPIGTLGAIWKQAQLGDER

Download         Length: 195 bp

>T68072 NZ_CP017708:3287106-3287300 [Moorena producens JHB]
ATGAAAGTTAAAGAGGTACTTAAGCGATTAAAAAAAGATGGATGGTATCAAGTAAGAATGCGGGGAAGTCATAGAATTTT
AGCTCATCCTCAAAAGCCAGGTATTGTAGTAGTTCCAGGTAAGCTAAGTGATGAGATACCCATCGGAACATTAGGTGCAA
TTTGGAAACAAGCACAGTTAGGAGATGAACGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7776.94 Da        Isoelectric Point: 4.0863

>AT68072 WP_008189734.1 NZ_CP017708:3287297-3287512 [Moorena producens JHB]
MKKYAVIYEKGDTNWGAIVPDLPGCVSIGDTLEEVQENVKEAIALYLEVLVEKGEKIPQPQTQVGFVEIAA

Download         Length: 216 bp

>AT68072 NZ_CP017708:3287297-3287512 [Moorena producens JHB]
ATGAAAAAATATGCAGTAATTTATGAAAAAGGCGATACCAACTGGGGGGCAATTGTGCCAGATTTACCCGGTTGTGTTAG
TATTGGTGACACTTTGGAAGAAGTCCAAGAAAATGTTAAAGAGGCGATCGCACTTTATCTGGAAGTTTTGGTCGAAAAAG
GAGAAAAAATCCCTCAACCTCAAACCCAAGTCGGATTTGTAGAAATAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9FZA1

Antitoxin

Source ID Structure
AlphaFold DB F4Y188

References