Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3287106..3287512 Replicon chromosome
Accession NZ_CP017708
Organism Moorea producens JHB

Toxin (Protein)


Gene name hicA Uniprot ID A0A1D9FZA1
Locus tag BJP36_RS12475 Protein ID WP_071104008.1
Coordinates 3287106..3287300 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F4Y188
Locus tag BJP36_RS12480 Protein ID WP_008189734.1
Coordinates 3287297..3287512 (+) Length 72 a.a.

Genomic Context

BJP36_RS12445BJP36_RS12450BJP36_RS12475BJP36_RS12480BJP36_RS36480BJP36_RS12440BJP36_RS12455BJP36_RS12460BJP36_RS12465BJP36_RS12470BJP36_RS12485BJP36_RS12490BJP36_RS12495BJP36_RS12500
Location: 3283690..3283884 (195 bp)
Type: Others
Protein ID: Protein_2850
Location: 3283881..3284183 (303 bp)
Type: Others
Protein ID: WP_071104003.1
Location: 3287106..3287300 (195 bp)
Type: Toxin
Protein ID: WP_071104008.1
Location: 3287297..3287512 (216 bp)
Type: Antitoxin
Protein ID: WP_008189734.1
Location: 3282833..3283040 (208 bp)
Type: Others
Protein ID: Protein_2848
Location: 3283122..3283397 (276 bp)
Type: Others
Protein ID: WP_202970786.1
Location: 3284362..3285384 (1023 bp)
Type: Others
Protein ID: WP_071104004.1
Location: 3285643..3285801 (159 bp)
Type: Others
Protein ID: WP_071104005.1
Location: 3286037..3286219 (183 bp)
Type: Others
Protein ID: WP_071104006.1
Location: 3286216..3286407 (192 bp)
Type: Others
Protein ID: WP_071104007.1
Location: 3287617..3288477 (861 bp)
Type: Others
Protein ID: WP_071104009.1
Location: 3288539..3288760 (222 bp)
Type: Others
Protein ID: WP_071104010.1
Location: 3288889..3289836 (948 bp)
Type: Others
Protein ID: WP_008189727.1
Location: 3289982..3291640 (1659 bp)
Type: Others
Protein ID: WP_071104011.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BJP36_RS364803282833..3283040-208Protein_2848CopG family transcriptional regulator-
BJP36_RS124403283122..3283397-276WP_202970786.1DUF433 domain-containing protein-
BJP36_RS124453283690..3283884+195Protein_2850type II toxin-antitoxin system RelE/ParE family toxin-
BJP36_RS124503283881..3284183+303WP_071104003.1helix-turn-helix domain-containing protein-
BJP36_RS124553284362..3285384-1023WP_071104004.1hypothetical protein-
BJP36_RS124603285643..3285801-159WP_071104005.1type II toxin-antitoxin system HicB family antitoxin-
BJP36_RS124653286037..3286219-183WP_071104006.1type II toxin-antitoxin system HicA family toxin-
BJP36_RS124703286216..3286407-192WP_071104007.1hypothetical protein-
BJP36_RS124753287106..3287300+195WP_071104008.1type II toxin-antitoxin system HicA family toxinToxin
BJP36_RS124803287297..3287512+216WP_008189734.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BJP36_RS124853287617..3288477-861WP_071104009.1hypothetical protein-
BJP36_RS124903288539..3288760-222WP_071104010.1hypothetical protein-
BJP36_RS124953288889..3289836-948WP_008189727.1hypothetical protein-
BJP36_RS125003289982..3291640-1659WP_071104011.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7257.63 Da        Isoelectric Point: 11.0108

>T68072 WP_071104008.1 NZ_CP017708:3287106-3287300 [Moorena producens JHB]
MKVKEVLKRLKKDGWYQVRMRGSHRILAHPQKPGIVVVPGKLSDEIPIGTLGAIWKQAQLGDER

Download         Length: 195 bp

>T68072 NZ_CP017708:3287106-3287300 [Moorena producens JHB]
ATGAAAGTTAAAGAGGTACTTAAGCGATTAAAAAAAGATGGATGGTATCAAGTAAGAATGCGGGGAAGTCATAGAATTTT
AGCTCATCCTCAAAAGCCAGGTATTGTAGTAGTTCCAGGTAAGCTAAGTGATGAGATACCCATCGGAACATTAGGTGCAA
TTTGGAAACAAGCACAGTTAGGAGATGAACGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7776.94 Da        Isoelectric Point: 4.0863

>AT68072 WP_008189734.1 NZ_CP017708:3287297-3287512 [Moorena producens JHB]
MKKYAVIYEKGDTNWGAIVPDLPGCVSIGDTLEEVQENVKEAIALYLEVLVEKGEKIPQPQTQVGFVEIAA

Download         Length: 216 bp

>AT68072 NZ_CP017708:3287297-3287512 [Moorena producens JHB]
ATGAAAAAATATGCAGTAATTTATGAAAAAGGCGATACCAACTGGGGGGCAATTGTGCCAGATTTACCCGGTTGTGTTAG
TATTGGTGACACTTTGGAAGAAGTCCAAGAAAATGTTAAAGAGGCGATCGCACTTTATCTGGAAGTTTTGGTCGAAAAAG
GAGAAAAAATCCCTCAACCTCAAACCCAAGTCGGATTTGTAGAAATAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1D9FZA1

Antitoxin

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Source
ID
Structure
AlphaFold DBF4Y188

References