Detailed information of TA system TA068068

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3166616..3167486
• Replicon: chromosome
• Accession: NZ_CP017703
• Organism: Aeribacillus pallidus strain KCTC3564

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: AP3564_RS15730
• Protein ID: WP_094245937.1
• Coordinates: 3167013..3167486 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: AP3564_RS15725
• Protein ID: WP_094245917.1
• Coordinates: 3166616..3167023 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AP3564_RS15695	3162108..3162899	-	792	WP_157727981.1	hypothetical protein	-
AP3564_RS15700	3162917..3163279	-	363	WP_094245934.1	helix-turn-helix transcriptional regulator	-
AP3564_RS15705	3163535..3163942	-	408	WP_198318528.1	nucleotide pyrophosphohydrolase	-
AP3564_RS15710	3164037..3165218	+	1182	WP_040037972.1	IS701 family transposase	-
AP3564_RS15715	3165439..3166158	+	720	Protein_2942	IS256 family transposase	-
AP3564_RS15725	3166616..3167023	+	408	WP_094245917.1	nucleotidyltransferase domain-containing protein	Antitoxin
AP3564_RS15730	3167013..3167486	+	474	WP_094245937.1	DUF86 domain-containing protein	Toxin
AP3564_RS15735	3168051..3168917	+	867	WP_094245938.1	gamma-glutamyltransferase	-
AP3564_RS15740	3168980..3169279	+	300	WP_157727983.1	hypothetical protein	-
AP3564_RS15745	3169988..3170824	-	837	WP_094245940.1	fructoselysine 6-kinase	-
AP3564_RS15750	3170908..3171543	-	636	WP_094245941.1	SIS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3112535..3278812	166277
	-	flank	IS/Tn	-	-	3164037..3165218	1181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (14-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (9-99)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 18172.04 Da
• Isoelectric Point: 9.7768

>T68068 WP_094245937.1 NZ_CP017703:3167013-3167486 [Aeribacillus pallidus]
MKNDVILNKISVIERCIKRIHEEYENNPKNLENYTKQDSIILNLQRACEASIDLAMHMVAQKKLGLPQNSRDAFSLLEQH
GIITPFVSQKMKAMVGFRNIAVHDYQEINLTILQKILDHHLTDFTEFTKAIFFMSSKAGGADTRRPSMLFKQRHNSR

Nucleotide

• Length: 474 bp

>T68068 NZ_CP017703:3167013-3167486 [Aeribacillus pallidus]
ATGAAAAATGATGTCATTTTAAATAAAATTAGCGTGATCGAGCGGTGCATAAAGCGCATTCACGAAGAATATGAGAACAA
CCCGAAAAATTTAGAAAACTACACGAAGCAAGACTCCATTATCTTAAATCTCCAACGAGCATGTGAAGCAAGCATCGACC
TAGCGATGCACATGGTCGCACAGAAAAAGCTAGGCCTCCCCCAAAACAGTCGAGACGCTTTTTCTCTTTTAGAACAGCAC
GGCATCATCACTCCTTTTGTTTCACAAAAAATGAAAGCGATGGTCGGATTTAGAAACATCGCCGTTCACGACTACCAGGA
AATTAATTTGACCATTTTGCAAAAAATACTTGATCACCATCTAACCGACTTTACCGAGTTCACGAAAGCGATTTTTTTTA
TGAGCAGTAAAGCGGGCGGTGCAGATACGCGCCGTCCGAGCATGTTATTTAAGCAAAGACATAATTCAAGATAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15597.65 Da
• Isoelectric Point: 4.6889

>AT68068 WP_094245917.1 NZ_CP017703:3166616-3167023 [Aeribacillus pallidus]
MTEQIEPIIIEVLTETVSPYLIYLFGSTVAGHVHQDSDIDIAFLSDQKQLDHYERFMVAQELASRLHRDVDLVDLKQAST
VFQAQVVSNGKVIYCTNEQKKAEYEWRALKMYAKLNEERAEILRNINESGSVYEK

Nucleotide

• Length: 408 bp

>AT68068 NZ_CP017703:3166616-3167023 [Aeribacillus pallidus]
TTGACTGAACAGATCGAGCCAATCATTATTGAAGTGTTGACAGAAACGGTGTCCCCATATTTGATTTATTTGTTTGGATC
AACGGTTGCAGGACATGTTCATCAAGACAGCGACATTGATATCGCTTTTCTCAGCGACCAAAAACAATTGGATCATTATG
AACGATTTATGGTTGCGCAAGAATTGGCATCCAGGCTGCACCGGGACGTCGATCTTGTGGACCTCAAACAAGCAAGCACC
GTGTTTCAGGCGCAAGTGGTCAGTAACGGCAAAGTCATCTATTGTACAAATGAACAGAAAAAAGCCGAATATGAATGGAG
AGCCTTGAAGATGTATGCAAAATTGAATGAAGAACGCGCGGAAATCTTGCGAAACATTAATGAAAGCGGGTCGGTTTATG
AAAAATGA