Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1398576..1399212 Replicon chromosome
Accession NZ_CP017703
Organism Aeribacillus pallidus strain KCTC3564

Toxin (Protein)


Gene name mazF Uniprot ID A0A559UL17
Locus tag AP3564_RS06945 Protein ID WP_063388230.1
Coordinates 1398862..1399212 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A559UL22
Locus tag AP3564_RS06940 Protein ID WP_063388229.1
Coordinates 1398576..1398857 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP3564_RS06920 1394844..1395560 - 717 WP_063388225.1 rhomboid family intramembrane serine protease -
AP3564_RS06925 1395658..1396020 + 363 WP_094244992.1 holo-ACP synthase -
AP3564_RS20640 1396090..1397160 + 1071 WP_198318583.1 outer membrane lipoprotein carrier protein LolA -
AP3564_RS06935 1397274..1398428 + 1155 WP_094244994.1 alanine racemase -
AP3564_RS06940 1398576..1398857 + 282 WP_063388229.1 hypothetical protein Antitoxin
AP3564_RS06945 1398862..1399212 + 351 WP_063388230.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AP3564_RS06950 1399689..1400804 + 1116 WP_094244995.1 IS4 family transposase -
AP3564_RS06955 1401001..1401834 + 834 WP_094244996.1 STAS domain-containing protein -
AP3564_RS06960 1401834..1402196 + 363 WP_063388242.1 STAS domain-containing protein -
AP3564_RS06965 1402198..1402599 + 402 WP_063388232.1 anti-sigma regulatory factor -
AP3564_RS06970 1402609..1403616 + 1008 WP_066247065.1 PP2C family protein-serine/threonine phosphatase -
AP3564_RS06975 1403677..1404000 + 324 WP_063388234.1 anti-sigma factor antagonist -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1399689..1400804 1115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12963.99 Da        Isoelectric Point: 4.8669

>T68066 WP_063388230.1 NZ_CP017703:1398862-1399212 [Aeribacillus pallidus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDDALQISLGLIDF

Download         Length: 351 bp

>T68066 NZ_CP017703:1398862-1399212 [Aeribacillus pallidus]
TTGATTGTTAAACGCGGCGACGTTTATTTTGCTGATTTATCCCCTGTAGTTGGTTCAGAGCAAGGCGGCGTTCGTCCAGT
TTTAATTATCCAAAATGATATAGGGAATCGTTTTAGTCCAACGGTGATCGTAGCCGCTATTACAGCACAAATTCAAAAAG
CAAAATTGCCGACTCATGTTGAAATTGATGCGAAAAAATATGGATTTGAACGGGATTCGGTCATTTTGCTTGAGCAGATT
AGAACGATTGATAAACAACGGTTAACGGATAAAATTACCCATCTTGATGATGAAATGATGGATAAAGTGGACGATGCCTT
ACAAATCAGTTTAGGGCTGATCGATTTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.24 Da        Isoelectric Point: 7.0152

>AT68066 WP_063388229.1 NZ_CP017703:1398576-1398857 [Aeribacillus pallidus]
VSESSSTTEIIVRLPQALVSELDGIVKQENGNRSEFIYQAMKMYLRERKKRQIRESMRRGYMEMAKINLNIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT68066 NZ_CP017703:1398576-1398857 [Aeribacillus pallidus]
GTGTCTGAATCCAGCTCAACAACGGAAATTATTGTTCGATTGCCACAAGCACTTGTTTCTGAATTAGATGGAATCGTGAA
ACAGGAAAACGGAAACAGAAGTGAATTTATTTATCAAGCAATGAAAATGTATTTGAGAGAGCGTAAAAAACGCCAAATTC
GCGAGTCAATGAGACGCGGTTATATGGAAATGGCGAAGATCAATCTAAATATTGCATCGGAGGCTTTTCTGGCAGAGTAT
GAGGCTGAACACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A559UL17

Antitoxin

Source ID Structure
AlphaFold DB A0A559UL22

References