Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1603245..1603881 Replicon chromosome
Accession NZ_CP017694
Organism Geobacillus thermodenitrificans strain KCTC3902

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GD3902_RS07975 Protein ID WP_003253417.1
Coordinates 1603245..1603595 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0Q1ENP8
Locus tag GD3902_RS07980 Protein ID WP_008881474.1
Coordinates 1603600..1603881 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD3902_RS07965 1599710..1600198 - 489 WP_008881471.1 SprT family protein -
GD3902_RS17895 1600289..1600402 + 114 WP_087959817.1 cortex morphogenetic protein CmpA -
GD3902_RS07970 1600419..1602584 - 2166 WP_029761551.1 RNA-binding transcriptional accessory protein -
GD3902_RS07975 1603245..1603595 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GD3902_RS07980 1603600..1603881 - 282 WP_008881474.1 hypothetical protein Antitoxin
GD3902_RS07985 1604009..1605163 - 1155 WP_029761552.1 alanine racemase -
GD3902_RS07990 1605458..1606471 - 1014 WP_008881476.1 outer membrane lipoprotein carrier protein LolA -
GD3902_RS07995 1606551..1606940 - 390 WP_008881477.1 holo-ACP synthase -
GD3902_RS08000 1607081..1607698 + 618 WP_008881478.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T68063 WP_003253417.1 NZ_CP017694:c1603595-1603245 [Geobacillus thermodenitrificans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T68063 NZ_CP017694:c1603595-1603245 [Geobacillus thermodenitrificans]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTCGTTGGCTCAGAGCAGGGCGGCGTACGCCCCGT
GTTGGTGATCCAAAACGATATCGGTAATCGCTTTAGTCCGACGGTGATTGTGGCGGCGATTACGGCGCAAATCCAGAAGG
CGAAACTGCCGACGCATGTTGAAATCGATGCAAAACGCTACGGGTTTGAGCGCGATTCCGTCATTTTGCTTGAGCAAATT
CGTACGATTGATAAGCAACGGTTGACCGATAAAATTACCCACTTGGACGATGAAATGATGGATAAAGTTGATGAGGCGCT
GCAAATCAGCTTAGGATTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10627.09 Da        Isoelectric Point: 7.2027

>AT68063 WP_008881474.1 NZ_CP017694:c1603881-1603600 [Geobacillus thermodenitrificans]
VSESGATTEIVVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT68063 NZ_CP017694:c1603881-1603600 [Geobacillus thermodenitrificans]
GTGTCGGAATCTGGCGCAACAACGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACGGAACTGGACGGGCTTGTCAA
ACAGGAGAACGGCAATCGAAATGAACTCATTTATCAAGCGACGAAAATGTATATTCGTGAACGGAAAAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCCAAAATCAATTTATCTATTGCTTCTGAAGCGTTTCATGCCGAATAT
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1ENP8

References