Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1849670..1850306 Replicon chromosome
Accession NZ_CP017690
Organism Geobacillus thermodenitrificans strain ID-1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GTID1_RS09080 Protein ID WP_003253417.1
Coordinates 1849670..1850020 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0Q1ENP8
Locus tag GTID1_RS09085 Protein ID WP_008881474.1
Coordinates 1850025..1850306 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTID1_RS09065 1846135..1846623 - 489 WP_008881471.1 SprT family protein -
GTID1_RS09070 1846714..1846827 + 114 WP_087959817.1 cortex morphogenetic protein CmpA -
GTID1_RS09075 1846844..1849009 - 2166 WP_011886670.1 RNA-binding transcriptional accessory protein -
GTID1_RS09080 1849670..1850020 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GTID1_RS09085 1850025..1850306 - 282 WP_008881474.1 hypothetical protein Antitoxin
GTID1_RS09090 1850434..1851588 - 1155 WP_008881475.1 alanine racemase -
GTID1_RS09095 1851883..1852896 - 1014 WP_008881476.1 outer membrane lipoprotein carrier protein LolA -
GTID1_RS09100 1852976..1853365 - 390 WP_008881477.1 holo-ACP synthase -
GTID1_RS09105 1853506..1854123 + 618 WP_060475533.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T68062 WP_003253417.1 NZ_CP017690:c1850020-1849670 [Geobacillus thermodenitrificans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T68062 NZ_CP017690:c1850020-1849670 [Geobacillus thermodenitrificans]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTCGTTGGCTCAGAGCAGGGCGGCGTACGCCCCGT
GTTGGTGATCCAAAACGATATCGGTAATCGCTTTAGTCCGACGGTGATTGTGGCGGCGATTACGGCGCAAATCCAGAAGG
CGAAACTGCCGACGCATGTTGAAATCGATGCAAAACGCTACGGGTTTGAGCGCGATTCCGTCATTTTGCTTGAGCAAATT
CGTACGATTGATAAGCAACGGTTGACCGATAAAATTACCCACTTGGACGATGAAATGATGGATAAAGTTGATGAGGCGCT
GCAAATCAGCTTAGGATTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10627.09 Da        Isoelectric Point: 7.2027

>AT68062 WP_008881474.1 NZ_CP017690:c1850306-1850025 [Geobacillus thermodenitrificans]
VSESGATTEIVVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT68062 NZ_CP017690:c1850306-1850025 [Geobacillus thermodenitrificans]
GTGTCGGAATCTGGCGCAACAACGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACGGAACTGGACGGGCTTGTCAA
ACAGGAGAACGGCAATCGAAATGAACTCATTTATCAAGCGACGAAAATGTATATTCGTGAACGGAAAAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCCAAAATCAATTTATCTATTGCTTCTGAAGCGTTTCATGCCGAATAT
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1ENP8

References