Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2029869..2030383 Replicon chromosome
Accession NZ_CP017685
Organism Staphylococcus aureus strain CFSAN007835

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag AB525_RS10295 Protein ID WP_000581795.1
Coordinates 2029869..2030078 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag AB525_RS10300 Protein ID WP_000138930.1
Coordinates 2030090..2030383 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB525_RS10275 2025377..2026735 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AB525_RS10280 2026750..2027820 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
AB525_RS10285 2028138..2029340 + 1203 WP_001109939.1 rod shape-determining protein RodA -
AB525_RS10290 2029604..2029741 - 138 WP_000828354.1 hypothetical protein -
AB525_RS10295 2029869..2030078 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
AB525_RS10300 2030090..2030383 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
AB525_RS10305 2030549..2032033 + 1485 WP_000571562.1 cardiolipin synthase -
AB525_RS10310 2032061..2032708 + 648 WP_001187625.1 HD domain-containing protein -
AB525_RS10320 2033258..2034130 - 873 WP_000725802.1 membrane protein insertase YidC -
AB525_RS10325 2034216..2034857 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T68053 WP_000581795.1 NZ_CP017685:c2030078-2029869 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T68053 NZ_CP017685:c2030078-2029869 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT68053 WP_000138930.1 NZ_CP017685:c2030383-2030090 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT68053 NZ_CP017685:c2030383-2030090 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References