Detailed information of TA system TA068051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1858861..1859637
• Replicon: chromosome
• Accession: NZ_CP017685
• Organism: Staphylococcus aureus strain CFSAN007835

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: AB525_RS09305
• Protein ID: WP_000031109.1
• Coordinates: 1858861..1859013 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: AB525_RS09310
• Protein ID: WP_001251224.1
• Coordinates: 1859038..1859637 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB525_RS09280	1854726..1855547	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
AB525_RS09285	1856004..1857389	-	1386	WP_000116239.1	class II fumarate hydratase	-
AB525_RS09290	1857585..1857980	-	396	WP_000901019.1	hypothetical protein	-
AB525_RS13600	1858261..1858416	+	156	WP_157774266.1	hypothetical protein	-
AB525_RS09305	1858861..1859013	-	153	WP_000031109.1	hypothetical protein	Toxin
AB525_RS09310	1859038..1859637	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
AB525_RS09315	1859796..1860266	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
AB525_RS09320	1860271..1861398	-	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
AB525_RS09325	1861549..1862271	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
AB525_RS09330	1862264..1863721	-	1458	WP_000649916.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T68051 WP_000031109.1 NZ_CP017685:c1859013-1858861 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T68051 NZ_CP017685:c1859013-1858861 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGAGAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT68051 WP_001251224.1 NZ_CP017685:c1859637-1859038 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT68051 NZ_CP017685:c1859637-1859038 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
CAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4