Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 841241..841718 Replicon chromosome
Accession NZ_CP017685
Organism Staphylococcus aureus strain CFSAN007835

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB525_RS04220 Protein ID WP_000052076.1
Coordinates 841241..841429 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB525_RS04225 Protein ID WP_001059690.1
Coordinates 841458..841718 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB525_RS04190 837231..837752 + 522 WP_000824479.1 hypothetical protein -
AB525_RS04195 838093..838779 + 687 WP_001622483.1 thermonuclease family protein -
AB525_RS04200 839136..839336 + 201 WP_001059082.1 cold-shock protein -
AB525_RS04205 839833..840051 - 219 WP_000005884.1 hypothetical protein -
AB525_RS04210 840124..840396 - 273 WP_001004400.1 hypothetical protein -
AB525_RS04215 840484..841053 - 570 WP_001106662.1 hypothetical protein -
AB525_RS04220 841241..841429 - 189 WP_000052076.1 hypothetical protein Toxin
AB525_RS04225 841458..841718 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB525_RS04230 842059..842262 + 204 WP_061104847.1 sterile alpha motif-like domain-containing protein -
AB525_RS04235 842259..842495 - 237 WP_000368687.1 hypothetical protein -
AB525_RS04240 842719..843300 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AB525_RS04245 843373..843990 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
AB525_RS04250 844146..844640 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB525_RS04255 845039..845461 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
AB525_RS04260 845609..846325 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell / vWbp 807054..844640 37586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-85)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T68050 WP_000052076.1 NZ_CP017685:c841429-841241 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T68050 NZ_CP017685:c841429-841241 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT68050 WP_001059690.1 NZ_CP017685:c841718-841458 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT68050 NZ_CP017685:c841718-841458 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References