Detailed information of TA system TA068049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 813118..813647
• Replicon: chromosome
• Accession: NZ_CP017685
• Organism: Staphylococcus aureus strain CFSAN007835

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: AB525_RS04060
• Protein ID: WP_001103939.1
• Coordinates: 813330..813647 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: AB525_RS04055
• Protein ID: WP_001058494.1
• Coordinates: 813118..813327 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB525_RS04020	809448..809912	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
AB525_RS04030	810475..811581	-	1107	WP_000149511.1	site-specific integrase	-
AB525_RS04035	811571..812374	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
AB525_RS04040	812510..812713	+	204	WP_001045296.1	transcriptional regulator	-
AB525_RS04045	812749..812967	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
AB525_RS04050	812979..813125	+	147	WP_000784885.1	hypothetical protein	-
AB525_RS04055	813118..813327	+	210	WP_001058494.1	hypothetical protein	Antitoxin
AB525_RS04060	813330..813647	+	318	WP_001103939.1	DUF1474 family protein	Toxin
AB525_RS04065	813711..814580	+	870	WP_099112084.1	primase alpha helix C-terminal domain-containing protein	-
AB525_RS04070	814597..816054	+	1458	WP_000390453.1	virulence-associated E family protein	-
AB525_RS04075	816355..816717	+	363	WP_001039170.1	hypothetical protein	-
AB525_RS04080	816719..817003	+	285	WP_000998185.1	hypothetical protein	-
AB525_RS04085	817000..817641	+	642	WP_001019808.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sec / sell / vWbp	807054..844640	37586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T68049 WP_001103939.1 NZ_CP017685:813330-813647 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T68049 NZ_CP017685:813330-813647 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT68049 WP_001058494.1 NZ_CP017685:813118-813327 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT68049 NZ_CP017685:813118-813327 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59