Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2181160..2181689 Replicon chromosome
Accession NZ_CP017684
Organism Staphylococcus aureus strain CFSAN007847

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag AB520_RS11285 Protein ID WP_000621176.1
Coordinates 2181160..2181522 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag AB520_RS11290 Protein ID WP_000948331.1
Coordinates 2181519..2181689 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB520_RS11260 2178139..2178909 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
AB520_RS11265 2178884..2179363 - 480 WP_001190825.1 anti-sigma B factor RsbW -
AB520_RS11270 2179365..2179691 - 327 WP_001052491.1 anti-sigma factor antagonist -
AB520_RS11275 2179810..2180811 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
AB520_RS11285 2181160..2181522 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AB520_RS11290 2181519..2181689 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
AB520_RS11295 2181774..2182922 - 1149 WP_001281140.1 alanine racemase -
AB520_RS11300 2182988..2183347 - 360 WP_000581197.1 holo-ACP synthase -
AB520_RS11305 2183351..2183842 - 492 WP_001286801.1 PH domain-containing protein -
AB520_RS11310 2183835..2185412 - 1578 WP_001294646.1 PH domain-containing protein -
AB520_RS11315 2185405..2185884 - 480 WP_001287082.1 hypothetical protein -
AB520_RS11320 2186093..2186653 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T68042 WP_000621176.1 NZ_CP017684:c2181522-2181160 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T68042 NZ_CP017684:c2181522-2181160 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT68042 WP_000948331.1 NZ_CP017684:c2181689-2181519 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT68042 NZ_CP017684:c2181689-2181519 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References