Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1938324..1939121 Replicon chromosome
Accession NZ_CP017684
Organism Staphylococcus aureus strain CFSAN007847

Toxin (Protein)


Gene name - Uniprot ID A0A6B0C7N0
Locus tag AB520_RS09715 Protein ID WP_000525009.1
Coordinates 1938660..1939121 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag AB520_RS09710 Protein ID WP_001260487.1
Coordinates 1938324..1938647 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB520_RS09655 1933939..1934382 - 444 WP_001099007.1 single-stranded DNA-binding protein -
AB520_RS09660 1934382..1935029 - 648 WP_020444661.1 ERF family protein -
AB520_RS09665 1935030..1935566 - 537 WP_001004336.1 host-nuclease inhibitor Gam family protein -
AB520_RS09670 1935579..1935839 - 261 WP_048520333.1 DUF1108 family protein -
AB520_RS09675 1935932..1936093 - 162 WP_099119659.1 DUF1270 family protein -
AB520_RS09680 1936107..1936316 - 210 WP_000455728.1 hypothetical protein -
AB520_RS09685 1936329..1937042 - 714 WP_031925041.1 ORF6C domain-containing protein -
AB520_RS09690 1937099..1937308 + 210 WP_000772137.1 hypothetical protein -
AB520_RS09695 1937301..1937441 - 141 WP_000939495.1 hypothetical protein -
AB520_RS09700 1937456..1937899 - 444 WP_000435360.1 hypothetical protein -
AB520_RS09705 1937912..1938160 - 249 WP_000272859.1 helix-turn-helix domain-containing protein -
AB520_RS09710 1938324..1938647 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
AB520_RS09715 1938660..1939121 + 462 WP_000525009.1 hypothetical protein Toxin
AB520_RS09720 1939305..1939826 + 522 WP_099119660.1 hypothetical protein -
AB520_RS09725 1939819..1940289 + 471 WP_000183249.1 hypothetical protein -
AB520_RS09730 1940359..1941408 + 1050 WP_099119661.1 site-specific integrase -
AB520_RS09775 1942685..1943239 - 555 WP_000132893.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hysA / selk 1862217..1952199 89982


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18060.39 Da        Isoelectric Point: 4.5941

>T68036 WP_000525009.1 NZ_CP017684:1938660-1939121 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T68036 NZ_CP017684:1938660-1939121 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT68036 WP_001260487.1 NZ_CP017684:1938324-1938647 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT68036 NZ_CP017684:1938324-1938647 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0C7N0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References