Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849384..849861 Replicon chromosome
Accession NZ_CP017684
Organism Staphylococcus aureus strain CFSAN007847

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB520_RS04180 Protein ID WP_000052076.1
Coordinates 849384..849572 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB520_RS04185 Protein ID WP_001059690.1
Coordinates 849601..849861 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB520_RS04150 845337..845894 + 558 WP_000824491.1 hypothetical protein -
AB520_RS04155 846235..846921 + 687 WP_001574556.1 thermonuclease family protein -
AB520_RS04160 847278..847478 + 201 WP_001059082.1 cold-shock protein -
AB520_RS04165 847975..848193 - 219 WP_000005879.1 hypothetical protein -
AB520_RS04170 848255..848539 - 285 WP_001004401.1 hypothetical protein -
AB520_RS04175 848627..849196 - 570 WP_001106663.1 hypothetical protein -
AB520_RS04180 849384..849572 - 189 WP_000052076.1 hypothetical protein Toxin
AB520_RS04185 849601..849861 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB520_RS04190 850202..850405 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AB520_RS04195 850402..850638 - 237 WP_000368687.1 hypothetical protein -
AB520_RS04200 850863..851444 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AB520_RS04205 851517..852134 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
AB520_RS04210 852290..852784 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB520_RS04215 853183..853605 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
AB520_RS04220 853753..854469 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T68032 WP_000052076.1 NZ_CP017684:c849572-849384 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T68032 NZ_CP017684:c849572-849384 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT68032 WP_001059690.1 NZ_CP017684:c849861-849601 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT68032 NZ_CP017684:c849861-849601 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References