Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2125483..2125997 Replicon chromosome
Accession NZ_CP017682
Organism Staphylococcus aureus strain CFSAN007850

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag AB526_RS10940 Protein ID WP_000581792.1
Coordinates 2125483..2125692 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag AB526_RS10945 Protein ID WP_000138932.1
Coordinates 2125704..2125997 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB526_RS10920 2120991..2122349 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AB526_RS10925 2122364..2123434 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
AB526_RS10930 2123752..2124954 + 1203 WP_001109939.1 rod shape-determining protein RodA -
AB526_RS10935 2125218..2125355 - 138 WP_000828354.1 hypothetical protein -
AB526_RS10940 2125483..2125692 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
AB526_RS10945 2125704..2125997 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
AB526_RS10950 2126163..2127647 + 1485 WP_000571549.1 cardiolipin synthase -
AB526_RS10955 2127675..2128322 + 648 WP_001187630.1 HD domain-containing protein -
AB526_RS10970 2129235..2130107 - 873 WP_000725802.1 membrane protein insertase YidC -
AB526_RS10975 2130193..2130834 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T68025 WP_000581792.1 NZ_CP017682:c2125692-2125483 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T68025 NZ_CP017682:c2125692-2125483 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT68025 WP_000138932.1 NZ_CP017682:c2125997-2125704 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT68025 NZ_CP017682:c2125997-2125704 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References