Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 829653..830130 Replicon chromosome
Accession NZ_CP017682
Organism Staphylococcus aureus strain CFSAN007850

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AB526_RS04110 Protein ID WP_000052076.1
Coordinates 829653..829841 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AB526_RS04115 Protein ID WP_001059690.1
Coordinates 829870..830130 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB526_RS04080 825647..826168 + 522 WP_000824482.1 hypothetical protein -
AB526_RS04085 826509..827195 + 687 WP_000141557.1 thermonuclease family protein -
AB526_RS04090 827552..827752 + 201 WP_001059082.1 cold-shock protein -
AB526_RS04095 828244..828462 - 219 WP_000005886.1 hypothetical protein -
AB526_RS04100 828524..828808 - 285 WP_001004399.1 hypothetical protein -
AB526_RS04105 828896..829465 - 570 WP_001106654.1 hypothetical protein -
AB526_RS04110 829653..829841 - 189 WP_000052076.1 hypothetical protein Toxin
AB526_RS04115 829870..830130 - 261 WP_001059690.1 hypothetical protein Antitoxin
AB526_RS04120 830471..830674 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AB526_RS04125 830671..830907 - 237 WP_000349581.1 hypothetical protein -
AB526_RS04130 831132..831713 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
AB526_RS04135 831786..832403 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
AB526_RS04140 832558..833052 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AB526_RS04145 833451..833873 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AB526_RS04150 834021..834737 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T68016 WP_000052076.1 NZ_CP017682:c829841-829653 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T68016 NZ_CP017682:c829841-829653 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT68016 WP_001059690.1 NZ_CP017682:c830130-829870 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT68016 NZ_CP017682:c830130-829870 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References