Detailed information of TA system TA068015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 363716..364251
• Replicon: chromosome
• Accession: NZ_CP017682
• Organism: Staphylococcus aureus strain CFSAN007850

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A4P7P340
• Locus tag: AB526_RS01705
• Protein ID: WP_001103945.1
• Coordinates: 363928..364251 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: AB526_RS01700
• Protein ID: WP_001058486.1
• Coordinates: 363716..363925 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB526_RS01660	358766..359269	+	504	WP_000934799.1	single-stranded DNA-binding protein	-
AB526_RS01665	359321..359563	+	243	WP_000897044.1	30S ribosomal protein S18	-
AB526_RS01670	359802..360702	-	901	Protein_314	Abi family protein	-
AB526_RS01675	360704..361918	-	1215	WP_031765313.1	site-specific integrase	-
AB526_RS01680	362182..362907	-	726	WP_000668215.1	helix-turn-helix transcriptional regulator	-
AB526_RS01685	363080..363292	+	213	WP_001245562.1	helix-turn-helix transcriptional regulator	-
AB526_RS01690	363293..363565	+	273	WP_001138300.1	helix-turn-helix domain-containing protein	-
AB526_RS01695	363577..363723	+	147	WP_000784875.1	hypothetical protein	-
AB526_RS01700	363716..363925	+	210	WP_001058486.1	hypothetical protein	Antitoxin
AB526_RS01705	363928..364251	+	324	WP_001103945.1	DUF1474 family protein	Toxin
AB526_RS01710	364316..365185	+	870	WP_031765319.1	primase alpha helix C-terminal domain-containing protein	-
AB526_RS01715	365202..366659	+	1458	WP_031765320.1	virulence-associated E family protein	-
AB526_RS01720	366960..367322	+	363	WP_031765322.1	hypothetical protein	-
AB526_RS01725	367324..367608	+	285	WP_000998179.1	hypothetical protein	-
AB526_RS01730	367605..368246	+	642	WP_031765326.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12665.26 Da
• Isoelectric Point: 4.7124

>T68015 WP_001103945.1 NZ_CP017682:363928-364251 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T68015 NZ_CP017682:363928-364251 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT68015 WP_001058486.1 NZ_CP017682:363716-363925 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT68015 NZ_CP017682:363716-363925 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A4P7P340