Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2083924..2084438 Replicon chromosome
Accession NZ_CP017679
Organism Staphylococcus aureus strain CFSAN007883

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag AB478_RS10590 Protein ID WP_000581792.1
Coordinates 2083924..2084133 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag AB478_RS10595 Protein ID WP_000138934.1
Coordinates 2084145..2084438 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB478_RS10570 2079432..2080790 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AB478_RS10575 2080805..2081875 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
AB478_RS10580 2082193..2083395 + 1203 WP_001109939.1 rod shape-determining protein RodA -
AB478_RS10585 2083659..2083796 - 138 WP_000828354.1 hypothetical protein -
AB478_RS10590 2083924..2084133 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
AB478_RS10595 2084145..2084438 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
AB478_RS10600 2084604..2086088 + 1485 WP_000571549.1 cardiolipin synthase -
AB478_RS10605 2086116..2086763 + 648 WP_001187610.1 HD domain-containing protein -
AB478_RS10620 2087578..2088450 - 873 WP_000725802.1 membrane protein insertase YidC -
AB478_RS10625 2088536..2089177 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T67994 WP_000581792.1 NZ_CP017679:c2084133-2083924 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T67994 NZ_CP017679:c2084133-2083924 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCATATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT67994 WP_000138934.1 NZ_CP017679:c2084438-2084145 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT67994 NZ_CP017679:c2084438-2084145 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FF1


Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References