Detailed information of TA system TA067991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 840564..841096
• Replicon: chromosome
• Accession: NZ_CP017679
• Organism: Staphylococcus aureus strain CFSAN007883

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: AB478_RS04210
• Protein ID: WP_001103942.1
• Coordinates: 840776..841096 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: AB478_RS04205
• Protein ID: WP_001058486.1
• Coordinates: 840564..840773 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB478_RS04160	835583..836803	-	1221	WP_000266157.1	site-specific integrase	-
AB478_RS04165	836892..837620	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
AB478_RS04170	837644..838372	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
AB478_RS04175	838442..838873	-	432	WP_001228759.1	hypothetical protein	-
AB478_RS04180	838890..839348	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
AB478_RS04185	839360..839692	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
AB478_RS04190	839885..840148	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
AB478_RS04195	840141..840413	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
AB478_RS04200	840425..840571	+	147	WP_000784875.1	hypothetical protein	-
AB478_RS04205	840564..840773	+	210	WP_001058486.1	hypothetical protein	Antitoxin
AB478_RS04210	840776..841096	+	321	WP_001103942.1	DUF1474 family protein	Toxin
AB478_RS04215	841160..842029	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
AB478_RS04220	842046..843515	+	1470	WP_000390454.1	virulence-associated E family protein	-
AB478_RS04230	843801..844163	+	363	WP_001039168.1	hypothetical protein	-
AB478_RS04235	844165..844449	+	285	WP_000998181.1	hypothetical protein	-
AB478_RS04240	844446..845087	+	642	WP_001019764.1	hypothetical protein	-
AB478_RS04245	845604..845945	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vWbp / selk / selq / seb	776778..867110	90332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T67991 WP_001103942.1 NZ_CP017679:840776-841096 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T67991 NZ_CP017679:840776-841096 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT67991 WP_001058486.1 NZ_CP017679:840564-840773 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT67991 NZ_CP017679:840564-840773 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4