Detailed information of TA system TA067990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 822869..823346
• Replicon: chromosome
• Accession: NZ_CP017679
• Organism: Staphylococcus aureus strain CFSAN007883

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: AB478_RS04060
• Protein ID: WP_000052076.1
• Coordinates: 822869..823057 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: AB478_RS04065
• Protein ID: WP_001059690.1
• Coordinates: 823086..823346 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB478_RS04015	818006..818326	-	321	WP_000805734.1	DUF961 family protein	-
AB478_RS04020	818477..818761	-	285	WP_000134542.1	hypothetical protein	-
AB478_RS04025	818907..819377	+	471	WP_099143893.1	hypothetical protein	-
AB478_RS04030	819718..820404	+	687	WP_001823812.1	thermonuclease family protein	-
AB478_RS04035	820761..820961	+	201	WP_001059082.1	cold-shock protein	-
AB478_RS04045	821460..821678	-	219	WP_000005888.1	hypothetical protein	-
AB478_RS04050	821740..822024	-	285	WP_001004397.1	hypothetical protein	-
AB478_RS04055	822112..822681	-	570	WP_001106657.1	hypothetical protein	-
AB478_RS04060	822869..823057	-	189	WP_000052076.1	hypothetical protein	Toxin
AB478_RS04065	823086..823346	-	261	WP_001059690.1	hypothetical protein	Antitoxin
AB478_RS04070	823687..823890	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
AB478_RS04075	823887..824123	-	237	WP_000368687.1	hypothetical protein	-
AB478_RS04080	824347..824928	+	582	WP_001140697.1	phosphoglycerate mutase family protein	-
AB478_RS04085	825001..825618	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
AB478_RS04090	825774..826268	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
AB478_RS04095	826667..827089	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
AB478_RS04100	827237..827953	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vWbp / selk / selq / seb	776778..867110	90332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T67990 WP_000052076.1 NZ_CP017679:c823057-822869 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T67990 NZ_CP017679:c823057-822869 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT67990 WP_001059690.1 NZ_CP017679:c823346-823086 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT67990 NZ_CP017679:c823346-823086 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56