Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4031254..4031732 Replicon chromosome
Accession NZ_CP017669
Organism Escherichia coli strain PA20

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AU473_RS21245 Protein ID WP_001303876.1
Coordinates 4031445..4031732 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AU473_RS21240 Protein ID WP_000536233.1
Coordinates 4031254..4031445 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AU473_RS21205 4026658..4027428 - 771 WP_000450992.1 DUF1627 domain-containing protein -
AU473_RS21210 4027450..4028196 - 747 WP_000788751.1 ATP-binding protein -
AU473_RS21215 4028203..4029294 - 1092 WP_001205823.1 hypothetical protein -
AU473_RS30700 4029373..4029828 + 456 WP_000273724.1 hypothetical protein -
AU473_RS21225 4030035..4030460 - 426 WP_000693855.1 Rha family transcriptional regulator -
AU473_RS21230 4030444..4030716 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AU473_RS21235 4030825..4031226 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AU473_RS21240 4031254..4031445 + 192 WP_000536233.1 hypothetical protein Antitoxin
AU473_RS21245 4031445..4031732 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AU473_RS21250 4032010..4032165 + 156 WP_000379575.1 DUF1391 family protein -
AU473_RS21255 4032307..4032696 + 390 WP_000394511.1 hypothetical protein -
AU473_RS21260 4032883..4033068 - 186 WP_001133046.1 hypothetical protein -
AU473_RS21270 4033642..4033830 + 189 WP_000413705.1 cell division inhibition protein DicB -
AU473_RS21275 4033827..4034018 + 192 WP_001098307.1 DUF1482 family protein -
AU473_RS21280 4034112..4036583 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T67955 WP_001303876.1 NZ_CP017669:4031445-4031732 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T67955 NZ_CP017669:4031445-4031732 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT67955 WP_000536233.1 NZ_CP017669:4031254-4031445 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT67955 NZ_CP017669:4031254-4031445 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References