Detailed information of TA system TA067932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 712671..713157
• Replicon: chromosome
• Accession: NZ_CP017667
• Organism: Streptococcus suis strain 1081

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BKM67_RS03650
• Protein ID: WP_105183716.1
• Coordinates: 712888..713157 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5AGV1
• Locus tag: BKM67_RS03645
• Protein ID: WP_002938604.1
• Coordinates: 712671..712898 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKM67_RS03615	708035..708580	-	546	WP_002941732.1	NAD(P)H-dependent oxidoreductase	-
BKM67_RS03620	708643..709092	-	450	WP_002938613.1	MarR family transcriptional regulator	-
BKM67_RS03625	709306..709803	+	498	WP_015646995.1	DUF5590 domain-containing protein	-
BKM67_RS03630	709800..710981	+	1182	WP_044668114.1	pyridoxal phosphate-dependent aminotransferase	-
BKM67_RS03635	710996..712342	+	1347	WP_105183718.1	asparagine--tRNA ligase	-
BKM67_RS03645	712671..712898	+	228	WP_002938604.1	hypothetical protein	Antitoxin
BKM67_RS03650	712888..713157	+	270	WP_105183716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BKM67_RS03655	713271..714590	+	1320	WP_105183715.1	MATE family efflux transporter	-
BKM67_RS03660	714774..715151	+	378	WP_024412168.1	RidA family protein	-
BKM67_RS03665	715173..716060	+	888	WP_024412169.1	RNase adapter RapZ	-
BKM67_RS03670	716057..717031	+	975	WP_024400159.1	YvcK family protein	-
BKM67_RS03675	717028..717945	+	918	WP_024400158.1	DNA-binding protein WhiA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10419.46 Da
• Isoelectric Point: 10.3916

>T67932 WP_105183716.1 NZ_CP017667:712888-713157 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGLMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Nucleotide

• Length: 270 bp

>T67932 NZ_CP017667:712888-713157 [Streptococcus suis]
ATGGCTTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGCTGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAAAATCCAAGACAGTTTGGCAAGGCCTTGGTTGGAGATTATAAGGGCC
TGTGGCGGTATCGTGTGGGAAATTACCGTGTGATTTGCGATATTATTGATAACAAAATGGTCATCCTAGCTCTTGAAATC
GGACACCGGAAGGAAATCTATAAAAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8450.51 Da
• Isoelectric Point: 4.1589

>AT67932 WP_002938604.1 NZ_CP017667:712671-712898 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Nucleotide

• Length: 228 bp

>AT67932 NZ_CP017667:712671-712898 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGGTTAAACGATGCAGAAGAAGAAATCTTCAGAAGCTATGCCATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A140EXF0