Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1005136..1005631 Replicon chromosome
Accession NZ_CP017666
Organism Streptococcus suis strain 0061

Toxin (Protein)


Gene name relE Uniprot ID A0A2Z4PJ37
Locus tag BKM66_RS04985 Protein ID WP_029171768.1
Coordinates 1005365..1005631 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2Z4PIY1
Locus tag BKM66_RS04980 Protein ID WP_024418295.1
Coordinates 1005136..1005375 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM66_RS04955 1000462..1001628 + 1167 WP_105184247.1 ATP-grasp domain-containing protein -
BKM66_RS10355 1001769..1001909 + 141 WP_032532220.1 hypothetical protein -
BKM66_RS04965 1001922..1002311 + 390 WP_105184248.1 NisI/SpaI family lantibiotic immunity lipoprotein -
BKM66_RS04970 1002320..1003072 + 753 WP_015646831.1 ABC transporter ATP-binding protein -
BKM66_RS04975 1003073..1005043 + 1971 WP_105184249.1 ABC transporter permease -
BKM66_RS04980 1005136..1005375 + 240 WP_024418295.1 hypothetical protein Antitoxin
BKM66_RS04985 1005365..1005631 + 267 WP_029171768.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKM66_RS04990 1005673..1006338 + 666 WP_105184250.1 response regulator transcription factor -
BKM66_RS04995 1006335..1007276 + 942 WP_105184251.1 sensor histidine kinase -
BKM66_RS05000 1007351..1008859 + 1509 WP_105123656.1 phosphomannomutase/phosphoglucomutase -
BKM66_RS05010 1009200..1010270 - 1071 WP_105115640.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) - 887539..1019831 132292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10274.01 Da        Isoelectric Point: 10.4518

>T67928 WP_029171768.1 NZ_CP017666:1005365-1005631 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRIIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T67928 NZ_CP017666:1005365-1005631 [Streptococcus suis]
TTGAGCTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATTGACGGGTGTGATAACCCCAGACAGTACGGAAAAGCCTTGACTGCCAATCGTTCTGGCC
AATGGCGGTATCGTATCGGCAATTACAGGATCATCGTCAGCATTGAGGATGATAAATTGATCGTAACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8835.12 Da        Isoelectric Point: 3.9191

>AT67928 WP_024418295.1 NZ_CP017666:1005136-1005375 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQADLAKGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT67928 NZ_CP017666:1005136-1005375 [Streptococcus suis]
ATGGCAGCTATCACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTACGACGCCCGTGTGGCAGATATTGCTTGGGCAG
AATACCAAGCAGACTTAGCAAAAGGAATTGAGCCAATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z4PJ37

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z4PIY1

References