Detailed information of TA system TA067927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 672389..672875
• Replicon: chromosome
• Accession: NZ_CP017666
• Organism: Streptococcus suis strain 0061

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BKM66_RS03370
• Protein ID: WP_105183716.1
• Coordinates: 672606..672875 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5AGV1
• Locus tag: BKM66_RS03365
• Protein ID: WP_002938604.1
• Coordinates: 672389..672616 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKM66_RS03335	667753..668298	-	546	WP_002941732.1	NAD(P)H-dependent oxidoreductase	-
BKM66_RS03340	668361..668810	-	450	WP_002938613.1	MarR family transcriptional regulator	-
BKM66_RS03345	669024..669521	+	498	WP_015646995.1	DUF5590 domain-containing protein	-
BKM66_RS03350	669518..670699	+	1182	WP_044668114.1	pyridoxal phosphate-dependent aminotransferase	-
BKM66_RS03355	670714..672060	+	1347	WP_105183718.1	asparagine--tRNA ligase	-
BKM66_RS03365	672389..672616	+	228	WP_002938604.1	hypothetical protein	Antitoxin
BKM66_RS03370	672606..672875	+	270	WP_105183716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BKM66_RS03375	672989..674308	+	1320	WP_105183715.1	MATE family efflux transporter	-
BKM66_RS03380	674492..674869	+	378	WP_024412168.1	RidA family protein	-
BKM66_RS03385	674891..675778	+	888	WP_024412169.1	RNase adapter RapZ	-
BKM66_RS03390	675775..676749	+	975	WP_024400159.1	YvcK family protein	-
BKM66_RS03395	676746..677663	+	918	WP_024400158.1	DNA-binding protein WhiA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10419.46 Da
• Isoelectric Point: 10.3916

>T67927 WP_105183716.1 NZ_CP017666:672606-672875 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGLMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Nucleotide

• Length: 270 bp

>T67927 NZ_CP017666:672606-672875 [Streptococcus suis]
ATGGCTTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGCTGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAAAATCCAAGACAGTTTGGCAAGGCCTTGGTTGGAGATTATAAGGGCC
TGTGGCGGTATCGTGTGGGAAATTACCGTGTGATTTGCGATATTATTGATAACAAAATGGTCATCCTAGCTCTTGAAATC
GGACACCGGAAGGAAATCTATAAAAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8450.51 Da
• Isoelectric Point: 4.1589

>AT67927 WP_002938604.1 NZ_CP017666:672389-672616 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Nucleotide

• Length: 228 bp

>AT67927 NZ_CP017666:672389-672616 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGGTTAAACGATGCAGAAGAAGAAATCTTCAGAAGCTATGCCATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A140EXF0