Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 272315..273573 Replicon chromosome
Accession NZ_CP017666
Organism Streptococcus suis strain 0061

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag BKM66_RS01390 Protein ID WP_105184197.1
Coordinates 272791..273573 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag BKM66_RS01385 Protein ID WP_105184196.1
Coordinates 272315..272791 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM66_RS01365 267614..269146 + 1533 WP_105184216.1 DUF853 family protein -
BKM66_RS01370 269304..270560 + 1257 WP_105137943.1 ISL3 family transposase -
BKM66_RS01375 270680..271294 + 615 WP_044751282.1 CoA pyrophosphatase -
BKM66_RS01380 271338..272006 - 669 WP_074391382.1 aquaporin -
BKM66_RS01385 272315..272791 + 477 WP_105184196.1 helix-turn-helix domain-containing protein Antitoxin
BKM66_RS01390 272791..273573 + 783 WP_105184197.1 zeta toxin family protein Toxin
BKM66_RS01395 273577..274653 + 1077 WP_192874038.1 SIR2 family protein -
BKM66_RS01400 274665..276388 + 1724 Protein_235 ATP-binding protein -
BKM66_RS01405 276908..277675 + 768 WP_105184198.1 DeoR/GlpR family DNA-binding transcription regulator -
BKM66_RS01415 277880..278302 + 423 WP_002941127.1 galactose-6-phosphate isomerase subunit LacA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 269304..270560 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 29736.67 Da        Isoelectric Point: 6.6138

>T67926 WP_105184197.1 NZ_CP017666:272791-273573 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQFLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDCIQIYQRDRTCIYDSKTYEGSAAEVLQEYLFGKWSKVEEEML
KMGQERLRELHKGSNKGMER

Download         Length: 783 bp

>T67926 NZ_CP017666:272791-273573 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTACTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAAGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTCTTAGCTTCGA
AAGGATACCAAGTTTCTTTAGCTGTCATTGGTACTAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATTGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACTGTATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGTATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATACCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGATGGGGCAGGAACGGTTGAGGGAATTGCACAAAGGAAGTAATAAGGGAATGGAGAGATAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18337.80 Da        Isoelectric Point: 4.4821

>AT67926 WP_105184196.1 NZ_CP017666:272315-272791 [Streptococcus suis]
MIGDNIKSLRQTHDLTQPEFAKMVGISRNSLSRYENGTSKVSTELIDRICQKFNVSYIDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELIHTKIYLVETFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT67926 NZ_CP017666:272315-272791 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCAGACACACGATTTAACACAACCAGAATTTGCGAAAATGGTCGGTATTTC
ACGCAATAGCCTAAGTCGTTATGAGAATGGAACTAGTAAAGTTTCAACAGAACTCATCGATCGTATTTGTCAGAAGTTTA
ACGTTTCTTATATCGATATTGTAGGGGAGGACAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
AACAAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCCATACGAAAATTTACCTTGTCGAGACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGATATGGTACATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References