Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 112975..114581 Replicon plasmid unnamed2
Accession NZ_CP017664
Organism Cronobacter sp. JZ38

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BJP61_RS21435 Protein ID WP_171999703.1
Coordinates 113262..114581 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BJP61_RS21430 Protein ID WP_171999700.1
Coordinates 112975..113259 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP61_RS21415 108851..110599 - 1749 WP_171999694.1 IucA/IucC family siderophore biosynthesis protein -
BJP61_RS21420 110735..111946 + 1212 WP_171999696.1 MFS transporter -
BJP61_RS21425 111943..112830 + 888 WP_171999698.1 siderophore-interacting protein -
BJP61_RS21430 112975..113259 + 285 WP_171999700.1 helix-turn-helix domain-containing protein Antitoxin
BJP61_RS21435 113262..114581 + 1320 WP_171999703.1 type II toxin-antitoxin system HipA family toxin Toxin
BJP61_RS21440 114887..116668 + 1782 WP_171999705.1 malto-oligosyltrehalose trehalohydrolase -
BJP61_RS21445 116668..119199 + 2532 WP_171999707.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - clpV/tssH / hcp/tssD / vipB/tssC / vipA/tssB / iutA / iucC / iucB / iucA / mgtB 1..145842 145842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49320.36 Da        Isoelectric Point: 7.7972

>T67925 WP_171999703.1 NZ_CP017664:113262-114581 [Cronobacter sp. JZ38]
MRRTPRLALWMNGIPVGYWDKHNGEDRLHYLPDWIHDAQGRPLSLSLPFTPGNQPYRGARVRDYFDNLLPDSEGIRRRLA
TRYRAQSLEPFDLLAELGRDCVGAIQLLRDGEAPEGLYTIRARPLSTVDIAAMLRHTAASFPGQHGSDEELRLSIAGAQE
KTALLWHDGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCSVLLDAYGIPVARTQMAQFEEQKALIVERFDR
RLSGDKKWWLRLPQEDMCQAIGVSPLRKYQTDGGPGIGDIMTVLSRSEHAQADRAHFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNHQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELVGLSPAQVTEMIDELIA
ATPAAIARVEDALPTGFPSALAGQIFDGMRQQCARLVSA

Download         Length: 1320 bp

>T67925 NZ_CP017664:113262-114581 [Cronobacter sp. JZ38]
ATGCGCCGCACGCCGCGCCTGGCGCTCTGGATGAACGGCATCCCGGTCGGTTACTGGGATAAACATAACGGCGAGGACCG
GCTGCACTACCTTCCGGACTGGATCCATGACGCGCAGGGCAGGCCGCTCTCGCTGTCGTTGCCGTTCACGCCCGGCAATC
AGCCGTACCGCGGCGCGCGGGTACGCGATTACTTCGATAACCTGTTGCCGGACAGCGAAGGCATCCGGCGGCGTCTGGCG
ACGCGCTACCGGGCGCAAAGCCTGGAACCGTTCGATCTGCTGGCGGAGCTCGGACGCGACTGCGTCGGGGCAATCCAGCT
GCTGCGCGACGGTGAAGCGCCGGAAGGGCTGTATACCATTCGCGCGCGACCGCTCTCTACAGTGGATATCGCCGCGATGC
TGCGCCACACCGCTGCGTCTTTTCCCGGTCAACACGGTAGCGACGAGGAACTGCGGCTCTCCATCGCCGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGACGGGCAATGGTGCCTGCCTGAGGGCAATACGCCCACCACGCATATTTTCAAGCTCCC
CCTGGGGCTGGTGGGCAACATGCAGGCGGATATGCGCACCTCCATTGAAAACGAATGGCTCTGCTCGGTGCTGCTGGACG
CGTACGGCATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGAAGAGCAAAAAGCGCTGATCGTTGAGCGTTTCGACAGG
CGGCTGTCGGGTGATAAAAAGTGGTGGCTGCGCCTCCCGCAGGAGGACATGTGCCAGGCGATCGGCGTCTCGCCGCTGCG
TAAATATCAGACCGATGGCGGGCCGGGCATCGGCGATATCATGACTGTCCTGAGCCGCTCTGAACATGCGCAGGCCGACC
GCGCCCACTTTTTTCGCGCCCAGATTATCTTCTGGATCCTCGCGGCCACTGATGGTCACGCCAAAAACTTCAGCATCGCC
CATCTGCCCGGCAACCGCTATCACCTGACGCCGCTCTACGACGTGCTCTCCGCCTGGCCGGTCATCGGCCCCGGCAATCA
CCAGATTGCCTGGCAGAAGTGCAAACTTGCGATGGCGGTGCGCGGCAGCAGCAACTATTACCACCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGTCGGGCTGTCGCCTGCCCAGGTGACAGAGATGATTGACGAGCTTATCGCC
GCGACGCCGGCCGCGATCGCCCGTGTGGAGGATGCGCTCCCGACAGGCTTTCCGTCTGCGCTGGCCGGCCAGATCTTCGA
CGGCATGCGCCAGCAGTGCGCGCGCCTCGTGAGCGCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10636.05 Da        Isoelectric Point: 9.8265

>AT67925 WP_171999700.1 NZ_CP017664:112975-113259 [Cronobacter sp. JZ38]
MNTVYPLKTLSQLRPLLVGFRKNQGLTQKEVSERLGVTQQTYARLEANPATASIERLFRVFNVLGIEIALSETQATSERE
TTARDDSPARREAW

Download         Length: 285 bp

>AT67925 NZ_CP017664:112975-113259 [Cronobacter sp. JZ38]
ATGAACACGGTATATCCACTGAAGACGCTCAGCCAGTTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAATCAGGGGCTGAC
CCAGAAAGAGGTGTCTGAACGGCTCGGCGTGACGCAGCAGACCTACGCCCGCCTGGAGGCTAACCCGGCCACAGCCAGCA
TTGAGCGTCTGTTCCGGGTGTTTAACGTGCTCGGTATTGAAATCGCGCTCAGCGAAACGCAGGCCACATCAGAGCGTGAG
ACCACCGCGCGCGACGACTCGCCCGCCCGTCGCGAGGCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References