Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3393981..3394600 Replicon chromosome
Accession NZ_CP017662
Organism Cronobacter sp. JZ38

Toxin (Protein)


Gene name Hha Uniprot ID K8B192
Locus tag BJP61_RS16115 Protein ID WP_007713751.1
Coordinates 3394382..3394600 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2T7AZ43
Locus tag BJP61_RS16110 Protein ID WP_038864291.1
Coordinates 3393981..3394355 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP61_RS16100 3389101..3390306 + 1206 WP_038864289.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BJP61_RS16105 3390328..3393477 + 3150 WP_075192156.1 multidrug efflux RND transporter permease subunit AcrB -
BJP61_RS16110 3393981..3394355 + 375 WP_038864291.1 Hha toxicity modulator TomB Antitoxin
BJP61_RS16115 3394382..3394600 + 219 WP_007713751.1 hemolysin expression modulator Hha Toxin
BJP61_RS16120 3394830..3395381 + 552 WP_038864292.1 maltose O-acetyltransferase -
BJP61_RS16125 3395501..3396010 + 510 WP_038864293.1 YlaC family protein -
BJP61_RS16130 3396039..3396179 - 141 WP_007713754.1 type B 50S ribosomal protein L36 -
BJP61_RS16135 3396183..3396443 - 261 WP_038864295.1 type B 50S ribosomal protein L31 -
BJP61_RS16140 3396589..3398490 - 1902 WP_075192154.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.06 Da        Isoelectric Point: 9.4828

>T67924 WP_007713751.1 NZ_CP017662:3394382-3394600 [Cronobacter sp. JZ38]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T67924 NZ_CP017662:3394382-3394600 [Cronobacter sp. JZ38]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTCAGACGCTGTCAGACAATTGATACGCTGGAACGTGT
GATTGAAAAAAATAAATATGAATTGCCTGACAATGAACTGGCGGTATTTTATTCAGCTGCAGATCATCGTCTCGCTGAAC
TGACCATGAATAAGCTTTACGATAAAATCCCAACCTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14371.06 Da        Isoelectric Point: 4.7168

>AT67924 WP_038864291.1 NZ_CP017662:3393981-3394355 [Cronobacter sp. JZ38]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHDEDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASRENPVSLSF

Download         Length: 375 bp

>AT67924 NZ_CP017662:3393981-3394355 [Cronobacter sp. JZ38]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTCGC
CACGCTAGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACATCCGCCGTTAACCTGCAACTGAACGATCTGATTGAGC
ATATTGCCAGTTTCGGTCTTAATTATAAAATTAAGCATGACGAAGATGCCGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACTTTTATGCTTTTCAGCAATTACGGTATCAATGCGCAAGATTTGCAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCCGGGAGAATCCTGTGAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8B192

Antitoxin

Source ID Structure
AlphaFold DB A0A2T7AZ43

References