Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1052626..1053289 Replicon chromosome
Accession NZ_CP017662
Organism Cronobacter sp. JZ38

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T7API2
Locus tag BJP61_RS04965 Protein ID WP_038868005.1
Coordinates 1052873..1053289 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2T7API5
Locus tag BJP61_RS04960 Protein ID WP_038868003.1
Coordinates 1052626..1052892 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP61_RS04940 1049190..1049918 - 729 WP_038867994.1 MurR/RpiR family transcriptional regulator -
BJP61_RS04945 1050097..1050411 + 315 WP_161579709.1 N(4)-acetylcytidine aminohydrolase -
BJP61_RS04950 1050576..1051229 + 654 WP_161579708.1 hemolysin III family protein -
BJP61_RS04955 1051360..1052349 - 990 WP_038868000.1 tRNA-modifying protein YgfZ -
BJP61_RS04960 1052626..1052892 + 267 WP_038868003.1 FAD assembly factor SdhE Antitoxin
BJP61_RS04965 1052873..1053289 + 417 WP_038868005.1 protein YgfX Toxin
BJP61_RS04970 1053321..1053842 - 522 WP_161579706.1 flavodoxin FldB -
BJP61_RS04975 1053944..1054840 + 897 WP_161579745.1 site-specific tyrosine recombinase XerD -
BJP61_RS04980 1054863..1055582 + 720 WP_171997920.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BJP61_RS04985 1055586..1057319 + 1734 WP_171997921.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16366.34 Da        Isoelectric Point: 11.6942

>T67914 WP_038868005.1 NZ_CP017662:1052873-1053289 [Cronobacter sp. JZ38]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYQLRWQGI
DWEICATPWMLRSGMMMRLRHPKTTRSHHVWLASDSMTPAEWRDLRRLLLQQPVRGSR

Download         Length: 417 bp

>T67914 NZ_CP017662:1052873-1053289 [Cronobacter sp. JZ38]
GTGGTCCTGTGGCACTCTGATCTTCGCGTCTCATGGCGCTCTCAGTGGGTATCGCTGCTGCTGCACGGCGCTGTGGCCGT
TATTATTTTGTTGCTTCCGTGGCCGCTGCGGTATCTGCCCGTCTGGATGTTGCTGCTGTCGCTGGTGGTGTTTGACTGCG
TTCGCAGCCAGCGACGTATCAACGCCTTTCAGGGGGAGGTAAGCCTCACGGCGGACTATCAGCTACGCTGGCAGGGCATC
GACTGGGAGATTTGCGCCACGCCCTGGATGTTACGCAGCGGCATGATGATGCGCCTGCGCCATCCCAAAACGACGCGCAG
CCACCATGTGTGGCTGGCATCGGACAGCATGACGCCGGCAGAGTGGCGGGATTTGCGTCGACTGTTACTGCAACAGCCGG
TGCGGGGTAGCCGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10440.94 Da        Isoelectric Point: 5.1295

>AT67914 WP_038868003.1 NZ_CP017662:1052626-1052892 [Cronobacter sp. JZ38]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDALSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
QERGPVAL

Download         Length: 267 bp

>AT67914 NZ_CP017662:1052626-1052892 [Cronobacter sp. JZ38]
ATGGATATTAACAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGTGAGCTGGATATTTCCATCATGCCTTT
CTTTGAGCACGACTATGACGCTCTGAGCGAAGAAGACAAACGCGTCTTTGTCCGCCTGCTGGAGTGTGACGACCCTGATT
TATTCAACTGGCTGATGAACCACGGCAAACCTGCCGATGCGGAACTGGCGCGGATGGTGCAATTGATCCAGCAACGGAAT
CAGGAACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T7API2

Antitoxin

Source ID Structure
AlphaFold DB A0A2T7API5

References