Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3130352..3131001 Replicon chromosome
Accession NZ_CP017660
Organism Cellulosimicrobium sp. JZ28

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BJP59_RS13995 Protein ID WP_194521208.1
Coordinates 3130579..3131001 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BJP59_RS13990 Protein ID WP_031315781.1
Coordinates 3130352..3130582 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJP59_RS13975 3127472..3128026 - 555 WP_021479810.1 hypoxanthine phosphoribosyltransferase -
BJP59_RS13980 3128032..3129132 - 1101 WP_194521207.1 tRNA lysidine(34) synthetase TilS -
BJP59_RS13985 3129136..3130350 - 1215 WP_194523074.1 zinc-dependent metalloprotease -
BJP59_RS13990 3130352..3130582 + 231 WP_031315781.1 antitoxin Antitoxin
BJP59_RS13995 3130579..3131001 + 423 WP_194521208.1 type II toxin-antitoxin system VapC family toxin Toxin
BJP59_RS14000 3131036..3132448 - 1413 WP_194521209.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
BJP59_RS14005 3132710..3133213 + 504 WP_034655165.1 inorganic diphosphatase -
BJP59_RS14010 3133278..3133901 - 624 WP_194521210.1 hypothetical protein -
BJP59_RS14015 3133895..3135238 - 1344 WP_194521211.1 cell wall-binding repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(6-42)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14990.02 Da        Isoelectric Point: 5.6065

>T67911 WP_194521208.1 NZ_CP017660:3130579-3131001 [Cellulosimicrobium sp. JZ28]
VSTLYLLDTNVLVALLRGHGAAARPRLREAEGRVAVSTVSEMELEYGVERSQDPARNRQAVDELLSLVDVLPFDSLAAMH
AGRVRAVLAARGTPGGPYDALLAGHARSLGLVLVTNNVREFSRVPGLEVEDWLADATHGP

Download         Length: 423 bp

>T67911 NZ_CP017660:3130579-3131001 [Cellulosimicrobium sp. JZ28]
GTGAGCACCCTCTATCTGCTGGACACGAACGTGCTCGTCGCCCTCCTCCGCGGGCACGGCGCGGCCGCGCGTCCGAGGCT
GCGCGAGGCAGAGGGGCGCGTCGCCGTCTCGACCGTGAGCGAGATGGAGCTGGAGTACGGCGTGGAGCGCTCGCAGGACC
CGGCCCGCAACCGGCAGGCGGTCGACGAGCTGCTGTCGCTCGTCGACGTGCTGCCCTTCGACAGCCTGGCGGCGATGCAC
GCCGGCAGGGTCCGCGCCGTCCTCGCGGCCCGCGGCACCCCTGGCGGCCCGTACGACGCGCTCCTCGCCGGGCACGCCCG
GTCGCTCGGGCTCGTGCTGGTGACGAACAACGTGCGCGAGTTCTCCCGCGTGCCCGGCCTGGAGGTCGAGGACTGGCTGG
CGGACGCGACGCACGGCCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8430.42 Da        Isoelectric Point: 7.0138

>AT67911 WP_031315781.1 NZ_CP017660:3130352-3130582 [Cellulosimicrobium sp. JZ28]
VRTTVFRSNRTQAVRLPKAVALPDDVREVDVRAVGRSRVITPAGSGWDEWFEHGLRVGPGFLADRDQGTADEREAL

Download         Length: 231 bp

>AT67911 NZ_CP017660:3130352-3130582 [Cellulosimicrobium sp. JZ28]
GTGCGCACGACGGTGTTCCGCAGCAACAGGACGCAGGCGGTCCGGCTGCCCAAGGCGGTCGCGCTGCCCGACGACGTCCG
GGAGGTGGACGTCCGGGCCGTCGGCCGGTCACGGGTCATCACCCCGGCCGGCTCCGGGTGGGACGAGTGGTTCGAGCACG
GCCTGCGCGTCGGTCCCGGCTTCCTCGCCGACCGTGACCAGGGCACCGCGGACGAGCGCGAGGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References