Detailed information of TA system TA067907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2754935..2755614
• Replicon: chromosome
• Accession: NZ_CP017656
• Organism: Acinetobacter baumannii strain KAB08

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KAB08_RS13195
• Protein ID: WP_000838146.1
• Coordinates: 2755432..2755614 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KAB08_RS13190
• Protein ID: WP_000966688.1
• Coordinates: 2754935..2755339 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB08_RS13170	2751947..2752939	-	993	WP_000835645.1	KilA-N domain-containing protein	-
KAB08_RS19965	2752936..2753091	-	156	WP_001103649.1	Arc family DNA-binding protein	-
KAB08_RS13175	2753214..2753453	+	240	WP_000763623.1	Arc family DNA-binding protein	-
KAB08_RS13180	2753502..2754296	-	795	WP_000720608.1	hypothetical protein	-
KAB08_RS13185	2754328..2754651	-	324	WP_000523922.1	DUF4236 domain-containing protein	-
KAB08_RS19970	2754660..2754836	-	177	WP_014466185.1	hypothetical protein	-
KAB08_RS13190	2754935..2755339	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KAB08_RS13195	2755432..2755614	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KAB08_RS13200	2755940..2756455	-	516	WP_038346477.1	hypothetical protein	-
KAB08_RS13205	2756526..2757443	-	918	WP_000094270.1	hypothetical protein	-
KAB08_RS13210	2757444..2758649	-	1206	WP_070469573.1	phage tail protein	-
KAB08_RS13215	2758649..2759002	-	354	WP_000064602.1	hypothetical protein	-
KAB08_RS13220	2759071..2759469	-	399	WP_000178914.1	hypothetical protein	-
KAB08_RS13225	2759471..2759839	-	369	WP_070439903.1	hypothetical protein	-
KAB08_RS13230	2759811..2760215	-	405	WP_000248222.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2738643..2785477	46834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T67907 WP_000838146.1 NZ_CP017656:c2755614-2755432 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T67907 NZ_CP017656:c2755614-2755432 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT67907 WP_000966688.1 NZ_CP017656:c2755339-2754935 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT67907 NZ_CP017656:c2755339-2754935 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6