Detailed information of TA system TA067902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2691741..2692420
• Replicon: chromosome
• Accession: NZ_CP017652
• Organism: Acinetobacter baumannii strain KAB06

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KAB06_RS12805
• Protein ID: WP_000838146.1
• Coordinates: 2692238..2692420 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: KAB06_RS12800
• Protein ID: WP_000966688.1
• Coordinates: 2691741..2692145 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAB06_RS12780	2688753..2689745	-	993	WP_000835645.1	KilA-N domain-containing protein	-
KAB06_RS19775	2689742..2689897	-	156	WP_001103649.1	Arc family DNA-binding protein	-
KAB06_RS12785	2690020..2690259	+	240	WP_000763623.1	Arc family DNA-binding protein	-
KAB06_RS12790	2690308..2691102	-	795	WP_000720608.1	hypothetical protein	-
KAB06_RS12795	2691134..2691457	-	324	WP_000523922.1	DUF4236 domain-containing protein	-
KAB06_RS19780	2691466..2691642	-	177	WP_014466185.1	hypothetical protein	-
KAB06_RS12800	2691741..2692145	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KAB06_RS12805	2692238..2692420	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KAB06_RS12810	2692746..2693261	-	516	WP_001185608.1	hypothetical protein	-
KAB06_RS12815	2693331..2694248	-	918	WP_000094250.1	hypothetical protein	-
KAB06_RS12820	2694301..2695455	-	1155	WP_070423368.1	phage tail protein	-
KAB06_RS12825	2695455..2695808	-	354	WP_015451444.1	hypothetical protein	-
KAB06_RS12830	2695904..2696122	-	219	WP_070423369.1	hypothetical protein	-
KAB06_RS12835	2696124..2696522	-	399	WP_001251850.1	hypothetical protein	-
KAB06_RS12840	2696524..2696892	-	369	WP_002055488.1	hypothetical protein	-
KAB06_RS12845	2696864..2697268	-	405	WP_000247948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2676173..2775530	99357

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T67902 WP_000838146.1 NZ_CP017652:c2692420-2692238 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T67902 NZ_CP017652:c2692420-2692238 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT67902 WP_000966688.1 NZ_CP017652:c2692145-2691741 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT67902 NZ_CP017652:c2692145-2691741 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6